Method for preparing of high purity acarbose

A technology of acarbose and acarbose, applied in the field of preparation of high-purity acarbose, can solve the problems of high removal cost, low yield, and high impurity A, and achieve the effect of low cost

Active Publication Date: 2007-08-01
HUADONG MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome defects such as the high content of impurity A in the acarbose produced by the prior art, the high cost of removal, and low yield, and to provide a low impurity A content, low cost, and easy industrial production. The preparation method of acarbose

Method used

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  • Method for preparing of high purity acarbose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] First put the acarbose feed liquid in the tank and wrap the used glass column tightly with cotton. The interlayer of the glass column is filled with frozen water. The filter equipment used and the bucket or beaker for storing the feed liquid are placed in ice cooling. In order to ensure the insulation effect as much as possible. At the same time, the temperature of the feed liquid is monitored by a thermometer.

[0024] After fermentation, the acarbose feed liquid is put into tanks, and plate and frame filtration, resin desalination and resin pre-chromatography are performed. During the whole process, the storage tanks and pipelines are insulated, and plate heat exchangers are installed in the pipelines. The device cools down. At the same time, the temperature of the feed liquid is strictly controlled by a thermometer. If the temperature is too high, increase the flow of chilled water or add ice cubes.

[0025] Through the above control, the temperature of the feed li...

Embodiment 2

[0032] First put the acarbose feed liquid into the tank to get the acarbose feed liquid to pass through the feed liquid pipeline and the storage tank with a polypropylene foam tube and wrap the skin tightly with aluminum skin to ensure the heat preservation effect as much as possible. At the same time, stainless steel spiral plate heat exchangers and temperature probes are installed in each feed liquid pipeline.

[0033] After fermentation, put the acarbose feed liquid into the tank, and perform plate-and-frame filtration, resin desalination and resin pre-chromatography operations. During the whole process, the storage tank and pipelines are kept warm, and heat exchangers are installed in the pipelines for further processing. Cool down. At the same time, the temperature of the feed liquid is strictly controlled through the temperature probe. If the temperature is too high, the flow of chilled water should be increased.

[0034] Through the above control, the temperature of th...

Embodiment 3

[0041] First put the acarbose feed liquid into the tank to obtain the acarbose feed liquid, and wrap the feed liquid pipeline and the storage tank with rubber and plastic materials tightly with adhesive tape to ensure the heat preservation effect as much as possible. At the same time, stainless steel spiral plate heat exchangers and temperature probes are installed in each feed liquid pipeline.

[0042] After fermentation, put the acarbose feed liquid into the tank, and perform plate-and-frame filtration, resin desalination and resin pre-chromatography operations. During the whole process, the storage tank and pipelines are kept warm, and heat exchangers are installed in the pipelines for further processing. Cool down. At the same time, the temperature of the feed liquid is strictly controlled through the temperature probe. If the temperature is too high, the flow rate of the ice brine is increased.

[0043] Through the above control, the temperature of the feed liquid is con...

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Abstract

The invention discloses a method for preparing high- purity acarbose. The foreign substance A content in purified acarbose is far behind pharmacopeia standard by controlling the temperature being 0- 25 Deg. C during pretreating process. The invention is characterized by low production cost and suitability for industrial production.

Description

technical field [0001] The invention relates to a preparation method of acarbose, more specifically to a preparation method of high-purity acarbose whose impurity A content is less than the pharmacopoeia standard. Background technique [0002] Acarbose (Acarbose) is an α-glucosidase inhibitor, which can be used orally as an antidiabetic drug for the treatment of type II diabetes. Acarbose is obtained through bacterial culture and fermentation. [0003] In the industrialized production of acarbose, impurity A (impurity A) is an isomer of acarbose. In high-performance liquid phase detection, because the retention time of HPLC is very close to that of acarbose, the impurity A in Acarbose Wave sugar is difficult to separate during extraction. At the same time, in the high-end market of acarbose, the requirements for impurity A are very high. For example, the European Pharmacopoeia version 5.1 requires the content of impurity A to be less than 0.6%. Therefore, how to effective...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/26C07H1/06
Inventor 周鲁瑾何志勇陈喆明赵庆委
Owner HUADONG MEDICINE
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