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Glycyrrhizic acid matrine salt and glycyrrhizic acid marine salt, its preparing method and use

A technology of pyranosidonic acid matrine salt and glycyrrhizic acid, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, steroids, etc., and can solve the problem of undisclosed ratio of glycyrrhizic acid without giving therapeutic effect And other problems such as matrine complex salt, to achieve a good curative effect

Active Publication Date: 2007-08-08
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese invention patent application CN1583783A "A double salt of glycyrrhizic acid and its preparation method and use" discloses a double salt made of glycyrrhizic acid and matrine, but he only discloses that the ratio of glycyrrhizic acid and matrine is Compositions within the range, did not give the ratio that can achieve the best therapeutic effect, and did not disclose that glycyrrhizic acid and matrine can obtain stable double salts

Method used

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  • Glycyrrhizic acid matrine salt and glycyrrhizic acid marine salt, its preparing method and use
  • Glycyrrhizic acid matrine salt and glycyrrhizic acid marine salt, its preparing method and use
  • Glycyrrhizic acid matrine salt and glycyrrhizic acid marine salt, its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 18β-glycyrrhizinic acid matrine salt

[0037] Add 165g of 18β-glycyrrhizinic acid and 49.7g of matrine into an appropriate amount of anhydrous methanol, stir to dissolve at room temperature, continue to stir for several minutes, then slowly add to 3000ml of acetone that is vigorously stirred, a large amount of white crystalline powder precipitates, filter, and store at 60°C Vacuum drying gave 172 g of white crystalline powder with a yield of 80.1%.

[0038] mp: decomposition at 204°C

[0039] [ C ] 20 D = + 24.5 (1% ethanol)

[0040] Elemental analysis

Embodiment 2

[0041] Example 2 18β-glycyrrhizinate matrine salt

[0042]Add 165g of 18β-glycyrrhizinic acid and 106g of matrine into an appropriate amount of absolute ethanol, stir to dissolve at room temperature, continue to stir for a few minutes, then slowly add to 3000ml of acetone that is vigorously stirred, a large amount of white crystalline powder precipitates, filter, and vacuum at 60°C After drying, 188 g of white crystalline powder was obtained, and the yield was 69.4%.

[0043] mp: decomposition at 206°C

[0044] [ C ] 20 D = + 42.4 (1% ethanol)

[0045] Elemental analysis

Embodiment 3

[0046] Example 3 18α-Glycyrrhizinic acid matrine salt

[0047] Add 165g of 18α-glycyrrhizinic acid and 49.7g of matrine into an appropriate amount of anhydrous methanol, stir to dissolve at room temperature, continue to stir for several minutes, then slowly add to 3000ml of acetone that is vigorously stirred, a large amount of white crystalline powder precipitates, filter, and store at 60°C Vacuum dried to obtain 180 g of white crystalline powder. The yield was 83.8%.

[0048] mp: decomposition at 208°C

[0049] [ C ] 20 D = + 23.6 (1% ethanol)

[0050] Elemental analysis

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PUM

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Abstract

The invention discloses a new synthesizing method of glycyrrhizin matrine salt and glycyrrhizin sophora flavescent salt, which also provides epimer 18-beta or 18-alpha glycyrrhizin sophora flavescent salt and their manufacturing method and application to make liver disease drug.

Description

technical field [0001] The present invention relates to a medicine that can be used for the treatment of liver diseases, specifically a salt formed by combining glycyrrhizic acid with matrine or matrine, and the salt is 18-alpha glycyrrhizic acid or 18-beta glycyrrhizic acid, which are different epimers of glycyrrhizic acid A salt formed by combining acid with matrine or matrine. Background technique [0002] Glycyrrhizin (G1ycyrrhizin, GC) is an effective active ingredient extracted from licorice. Its biological activity has been extensively studied at home and abroad and has been used clinically for many years. It has anti-inflammatory, anti-allergic, anti-biological oxidation, immune function regulation, block Ca 2+ Influx, dissociation of adrenal cortex hormone and stabilization of lysosomal membrane and other pharmacological effects, among which anti-inflammatory effect is the main mechanism of glycyrrhizic acid against liver injury. [0003] Matrine and matrine are t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61K31/7056A61P1/16
Inventor 张爱明徐宏江王祥建杨玲张喜全
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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