Composition for treating asthma and preparing process thereof

A composition and asthma technology, applied in the field of medicine, can solve problems such as poor quality controllability, large dosage, and mixing of inactive substances, and achieve the effect of easy quality control and reduced dosage

Inactive Publication Date: 2007-08-15
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these compounds containing Schisandra chinensis and Asarum for the treatment of asthma have been clinically proven to have good curative effect, the combination of Schisandra chinensis and Asarum has also been proved to have good anti-asthma, antitussive and expectorant effects through pharmacological experiments. The dose is also large, the active substance is mixed with a large number of inactive substances, the material basis and mechanism of anti-asthma effect are difficult to study, the toxicity and side effects are difficult to study, and the quality controllability is poor.

Method used

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  • Composition for treating asthma and preparing process thereof
  • Composition for treating asthma and preparing process thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Preparation of volatile oil of Schisandra chinensis: 168g of schisandra chinensis was crushed into 10-mesh powder, added 8 times of water, soaked to the heart, extracted by steam distillation for 4 hours, and volatile oil of schisandra chinensis was obtained. Preparation of total acid of Schisandra chinensis: Suction filtration of the water extract obtained after extracting volatile oil from 168g of Schisandra chinensis, collecting the filtrate, adding 8 times of water to the filter residue, decocting and extracting for 1 hour, suction filtration, combining two filtrates, and concentrating under reduced pressure at 60°C to relative The density is 0.10, exchange on HZ201 strong basic anion exchange column, the flow rate is 1 ~ 2BV / h, wash with deionized water until neutral after exchange, discard the deionized water eluate, and elute with 0.5M hydrochloric acid 70% ethanol solution , flow rate 1-2BV / h, 12 BV elution, collect eluate, concentrate under reduced pressure, eva...

Embodiment 2

[0024] Preparation of volatile oil of Schisandra chinensis: 168g of schisandra chinensis was crushed into 5-mesh powder, added 10 times of water, soaked to the heart, extracted by steam distillation for 6 hours, and volatile oil of schisandra chinensis was obtained. Preparation of total acid of Schisandra chinensis: Suction filtration of the water extract obtained after extracting volatile oil from 168g of Schisandra chinensis, collecting the filtrate, adding 5 times water to the filter residue, decocting for 1 hour, suction filtration, combining the two filtrates, and concentrating under reduced pressure at 60°C to relative The density is 0.10, exchange on HZ201 strong basic anion exchange column, the flow rate is 1 ~ 2BV / h, wash with deionized water until neutral after exchange, discard the deionized water eluate, and elute with 0.5M hydrochloric acid 70% ethanol solution , flow rate 1-2BV / h, 12 BV elution, collect eluate, concentrate under reduced pressure, evaporate at 60°C...

Embodiment 3

[0027] Preparation of volatile oil of Schisandra chinensis: 168g of schisandra chinensis was crushed into 20 mesh powder, added 5 times of water, soaked to the heart, extracted by steam distillation for 3 hours, and volatile oil of schisandra chinensis was obtained. Preparation of total acid of Schisandra chinensis: Suction filtration of the water extract obtained after extracting volatile oil from 168g of Schisandra chinensis, collecting the filtrate, adding 10 times water to the filter residue, decocting and extracting for 1 hour, suction filtration, combining two filtrates, and concentrating under reduced pressure at 60°C to relative The density is 0.10, exchange on HZ201 strong basic anion exchange column, the flow rate is 1 ~ 2BV / h, wash with deionized water until neutral after exchange, discard the deionized water eluate, and elute with 0.5M hydrochloric acid 70% ethanol solution , flow rate 1-2BV / h, 12 BV elution, collect eluate, concentrate under reduced pressure, evapo...

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Abstract

The invention discloses a medicinal composition for treating asthma and its preparation method, which belongs to the medicinal field. The composition contains (by weight part) volatile oil of Schisandra chinensis fruit 5.64-14.96, total acids of Schisandra chinensis fruit 70.54-89.14, and volatile oil of Herba Asari 5.22-14.50. The preparation method comprises crushing Schisandra chinensis fruit, sieving, soaking in water, performing steam distillation to obtain volatile oil, vacuum-filtering the resulting distillate, decocting the filter residue, vacuum-filtering, concentrating, separating with alkaline anion exchange resin, washing with deionized water to neutrality, and concentrating and drying the eluate to obtain total acids; slicing Herba Asari, soaking in water, and performing steam distillation to obtain volatile oil. The composition has antiasthmatic, antitussive and expectorant effects, and is used to treat different types of asthma.

Description

technical field [0001] The invention relates to a composition in the technical field of medicine and a preparation method thereof, in particular to a composition for treating asthma and a preparation method thereof. Background technique [0002] Asthma is a common and frequently-occurring disease that seriously endangers the health of the people. The annual medical expenditure of asthma patients is a huge number, which not only affects the patients themselves, but also affects the development of society, becoming a serious social health problem. Western medicine treatment is mainly based on glucocorticoids, which can effectively relieve symptoms, but the side effects are obvious. Traditional Chinese medicine treatment has good long-term curative effect and few side effects, especially in the treatment of the remission period of the disease, assisting Western medicine to consolidate the curative effect of the attack period, and reducing the side effects of Western medicine. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61P11/06A61P37/08
Inventor 贾伟邱明丰周明眉吴建兵褚襄萍
Owner SHANGHAI JIAO TONG UNIV
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