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Application of magnolia bark preparation in preparing medicine for treating diabetes and obesity

A technology for diabetes and obesity, which is applied in the application field of traditional Chinese medicine preparations, and can solve the problems that it cannot be used as a medicine and the production process is complicated.

Inactive Publication Date: 2007-08-15
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the PTP1B inhibitors discovered so far are peptides or highly toxic substances, such as non-selective PTP inhibitors vanadate and pervanadate, etc., which cannot be developed as drugs
Others such as Chinese patent CN1794989A, the PTP1B inhibitors mentioned are N-(((((1,3-thiazol-2-yl)amino)carbonyl)phenyl)sulfonyl)phenylalanine derivatives and related compounds , which needs to be obtained through multi-step chemical synthesis, and the production process is complicated

Method used

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  • Application of magnolia bark preparation in preparing medicine for treating diabetes and obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Get 600g of dried magnolia bark, grind and pulverize, and filter through a 40-mesh sieve to obtain 500g of magnolia bark dry powder.

Embodiment 2

[0033] Soak 350 g of Magnolia officinalis dry powder in Example 1 with 1500 ml of absolute ethanol and stir at a stirring speed of 60 rpm. After 3 hours, filter through 80 mesh and 120 mesh sieves to remove residues. The obtained filtrate was evaporated at 70-80° C. to remove ethanol through a rotary evaporator to obtain viscous Magnolia officinalis extract.

[0034] The traditional Chinese medicine Magnolia officinalis can also be directly soaked and stirred with ethanol, and the filter residue is evaporated to remove ethanol to obtain viscous Magnolia officinalis extract.

Embodiment 3

[0036] Heat the Magnolia officinalis extract in Example 2 at 80°C to dry to remove the remaining ethanol, and after the extract is completely dry, dissolve the dried ethanol extract in water and sterilize it by filling to prepare Magnolia officinalis Oral Liquid or Magnolia Magnolia Injection .

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PUM

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Abstract

The application of Magnolia officinalis preparation for the production of medicaments for treating diabetes and obesity belongs to the field of medicinal application. The Magnolia officinalis preparation is extracted from Magnolia officinalis by soaking in ethanol with magnolol and honokiol as main ingredients. The preparation has effects of in-vitro inhibiting the activity of protein-tyrosine phosphatase 1B (PTP1B) and reducing blood sugar level in rat model of type 2 diabetes. The preparation can be made into powder, pill, capsule, tablet, oral liquid and injection. It can be used for treating diabetes, obesity, and diseases related to PTP1B.

Description

technical field [0001] The invention belongs to the technical field of medical application of substances, and in particular relates to the application of magnolia bark preparations in the preparation of traditional Chinese medicine preparations for treating diabetes and obesity. Background technique [0002] Diabetes is clinically divided into two types: type I diabetes and type II diabetes, of which type II diabetes accounts for 80% to 90% of the total number of cases, and more than 100 million people in the world suffer from type II diabetes. The etiology of type II diabetes The main reason is that the resistance of body tissues to insulin and the relative lack of insulin secretion by pancreatic B cells. Insulin resistance refers to the biological response of the target organs or target tissues of insulin action, such as liver, muscle, and adipose tissue, to a certain amount of insulin, which is lower than expected. normal level. [0003] Although some medicines are clini...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61K9/08A61K9/10A61K9/20A61P3/04A61P3/10A61K125/00A61K129/00A61K135/00
Inventor 付学奇赵志壮李青山刘玉珊张鸿义邢述徐越驰李莹
Owner JILIN UNIV
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