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Preparation for cardiovascular or cerebrovascular disease and the preparing method

A technology for cardiovascular and cerebrovascular diseases and clear drop pills, which is applied in the field of medicine and can solve problems such as long disintegration time, reduced production costs, and low bioavailability

Inactive Publication Date: 2007-09-19
BEIJING YINKERUISI BIOLOGICAL PODUCTS RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new pharmaceutical preparation and its preparation method. The preparation is mainly prepared from persimmon leaf extract powder plus a suitable medicinal base; it can increase coronary and cerebral blood flow, improve heart and brain tissue The state of blood supply and oxygen supply can increase the electrophoretic rate of red blood cells; it is used for coronary heart disease, angina pectoris, cerebral arteriosclerosis, ischemic cerebrovascular disease, etc., and the clinical effect is remarkable. Disadvantages such as long solution time and slow onset time, for this reason, it is developed into a kind of new dosage form drop pill preparation in order to overcome above-mentioned deficiency, simultaneously the drop pill dosage form of the present invention has reduced production cost, is about 50% of common dosage form ; The quality controllability and drug stability are also greatly improved; at the same time, it also has small size, fast drug melting, increased absorption speed and bioavailability of active ingredients, and has quick-acting and high-efficiency effects, and is convenient to take and simple in process , easy to industrialize and benefit

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Persimmon Leaf Extract Powder 50g Polyethylene Glycol 4000 150g Polyethylene Glycol 6000 50g

[0040] Take dried persimmon leaves, add water and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.12-1.15 (60°C), add ethanol until the alcohol content reaches 85%, stand overnight, filter the supernatant for later use; wash the precipitate twice with 65% ethanol, collect the washing liquid, let it stand, absorb the supernatant and combine with the previous supernatant, recover the ethanol, and dissolve the obtained extract in water. Filtrate, extract the filtrate four times with ethyl acetate, combine the ethyl acetate solution, recover ethyl acetate, dry the thick paste at low temperature into a dry extract, grind it into fine powder, and set aside; polyethylene glycol 4000, polyethylene glycol Mix 6000 in a ratio of 3:1, heat to 90-100°C, add fine powder of persimmon lea...

Embodiment 2

[0042] Persimmon Leaf Extract Powder 50g Polyethylene Glycol 4000 300g Polyethylene Glycol 6000 50g

[0043] Take dried persimmon leaves, add water and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.12-1.15 (60°C), add ethanol until the alcohol content reaches 85%, stand overnight, filter the supernatant for later use; wash the precipitate twice with 65% ethanol, collect the washing liquid, let it stand, absorb the supernatant and combine with the previous supernatant, recover the ethanol, and dissolve the obtained extract in water. Filtrate, extract the filtrate four times with ethyl acetate, combine the ethyl acetate solution, recover ethyl acetate, dry the thick paste at low temperature into a dry extract, grind it into fine powder, and set aside; polyethylene glycol 4000, polyethylene glycol Mix 6000 in a ratio of 6:1, heat to 90-100°C, add fine powder of persimmon lea...

Embodiment 3

[0045] Persimmon Leaf Extract Powder 50g Polyethylene Glycol 4000 50g Polyethylene Glycol 6000 50g

[0046] Take dried persimmon leaves, add water and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.12-1.15 (60°C), add ethanol until the alcohol content reaches 85%, stand overnight, filter the supernatant for later use; wash the precipitate twice with 65% ethanol, collect the washing liquid, let it stand, absorb the supernatant and combine with the previous supernatant, recover the ethanol, and dissolve the obtained extract in water. Filtrate, extract the filtrate four times with ethyl acetate, combine the ethyl acetate solution, recover ethyl acetate, dry the thick paste at low temperature into a dry extract, grind it into fine powder, and set aside; polyethylene glycol 4000, polyethylene glycol Mix 6000 at a ratio of 1:1, heat to 90-100°C, add fine powder of persimmon leaf...

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PUM

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Abstract

The invention discloses a Naoxinqing preparation for treating cardio-cerebrovascular disease and a method for preparing the same, belonging to a medicine technology art. The preparation is formed mainly by kaki leaf extract powder and a medical substrate. The invention has reasonable substrate type, quantity and main material ratio, preferred one or both of polyethyleneglycol 4000 and polyethyleneglycol 400. The reasonablepreparing process of the invention has even and controllable quality, and can be directly used to instruct large-scale production; meanwhile the pill has advantages of less volume, high bioavailability, convenience for carrying, is rapid for releasing and easy for absorbing.

Description

technical field [0001] The invention relates to a Naoxinqing preparation for cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the technical field of medicine. technical background [0002] With the change of social environment and people's living habits, the incidence of cardiovascular and cerebrovascular diseases is increasing day by day, and has become the veritable number one killer. According to data, the mortality rate of cardiovascular and cerebrovascular diseases ranks second only after malignant tumors, accounting for 52% of the death toll due to diseases. China is gradually entering an aging society, and its incidence rate is showing a trend of significant increase. Therefore, research and development of such drugs can not only bring good market development opportunities for enterprises, but also make due contributions to the cause of human health. [0003] Research by medical experts has proved that the cause of cardiovasc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/44A61K9/20A61P9/10A61K127/00
Inventor 张保献
Owner BEIJING YINKERUISI BIOLOGICAL PODUCTS RES INST