Process for preparing superthin allogeneic bone nail

An allogeneic and preparation technology, applied in prosthesis, medical science, fixator, etc., can solve the problem of unsuitable internal fixation for small bone fractures, achieve good biocompatibility and degradability, and relieve pain. Effect

Inactive Publication Date: 2007-10-03
史铭祥
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

However, the developed allogeneic bone screws have a diameter of more than 3 mm, which is not suitable for internal fixation of small bone fractures.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Select allogeneic cortical bone fragments with a length of 15 mm, a width of 5 mm, and a height of 3 mm. After removing the periosteum and bone marrow, store them at -86°C for 30 days, take them out and rewarm them for 1.5 hours, cut them longitudinally into strips, and use a grinder. Grind threaded bone nails with a diameter of 0.8 mm and a length of 0.4 mm. After repeated washing with normal saline, soak in absolute ethanol for 2 hours, then put them in a mixture of absolute ether and acetone for 1 hour, air dry naturally, and then place Freeze-dry in a dryer at -30°C for 24 hours, take it out, put it in a packaging bag and vacuum-seal it, sterilize it with gamma rays, and store it at room temperature for later use. The manufactured bone nail was subjected to mechanical tests, and its mechanical parameters were as follows: ultimate compressive load 150.03MPa, ultimate flexural load 16.21MPa, ultimate tensile load 110.95MPa, and ultimate torsional load 101.4MPa.

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Abstract

A process for preparing the superfine allogenic bone nail includes such steps as choosing allogenic cortical bone piece (8-15mmX5-8mmX3-7mm), removing periosteum and marrow, storing at -50--86 deg.C for 30-35 days, recovering ordinary temp, longitudinal cutting grinding to become bone nail (0.8-1.5mmX0.4-1.0mm), flushing with physiologic saline, immersing it in absolute alcohol for 2 hr and then in the mixture of anhydrous ether and acetone for 1 hr, natural drying, freeze-drying at -30--55 deg.C for 24 hr, vacuum packing, and gamma-ray sterilizing.

Description

technical field [0001] The invention relates to a preparation process of a bone nail, in particular to a preparation process of an ultra-small-diameter allogeneic bone nail. Background technique [0002] There are many patients with small bone fractures caused by fractures of facet joints, metacarpophalangeals, etc. every year. At present, the traditional treatment method of this position fracture is to screw into the metal nail that plays a fixed role in the fracture, and after the bone is healed, a second operation is performed on the patient to take out the metal nail that has been nailed into the bone. The defect of this treatment method is that the second operation to take out the metal nail greatly increases the suffering of the patient, and the metal nail easily causes infection, inflammation and allergic reaction in the human body. [0003] There is a kind of allogeneic bone nail, which is made of cortical bone material, and can also be used to fix the fracture affe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61B17/58
Inventor 李五周
Owner 史铭祥
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