Chinese traditional medicine preparation in use for treating liver and gall disease, and preparation method

A technology for traditional Chinese medicine preparations and hepatobiliary diseases, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of color spots, long disintegration time of coated tablets, poor stability, etc.

Inactive Publication Date: 2007-10-10
BEIJING YINKERUISI BIOLOGICAL PODUCTS RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the drug was launched on the market, it has been welcomed by doctors and patients because of its definite curative effect and no obvious side effects. And the disintegration time of the coated tablet is longer

Method used

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  • Chinese traditional medicine preparation in use for treating liver and gall disease, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Artificial bezoar 30g Silymarin 17.5g Berberine hydrochloride 12.5g Corydalis 125g

[0064] Rhubarb 12.5g Dandelion 150g Desmodium 200g Peppermint Oil 2g

[0065] For the above eight flavors, get Corydalis Corydalis and rhubarb are properly pulverized, use 2 times the amount of 60% ethanol as solvent, soak for 24 hours and carry out percolation according to the current extract and extract item (Appendix 10 of Chinese Pharmacopoeia 2005 edition, one appendix 10), collect the The filtrate is concentrated below 70°C; dandelion and desmodium are decocted with water three times, each time adding 8 times the amount of water and decocted for 1.5 hours, filtered, and the filtrate is concentrated and added to the above concentrated solution to concentrate into a thick paste, dried, Make powder; add artificial bezoar, silymarin, berberine hydrochloride and appropriate amount of starch, mix evenly, granulate, dry, spray peppermint oil, add micronized silica gel 5g, mix evenly, pac...

Embodiment 2

[0067] Artificial bezoar 30g Silymarin 17.5g Berberine hydrochloride 12.5g Corydalis 125g

[0068] Rhubarb 12.5g Dandelion 150g Desmodium 200g Peppermint Oil 2g

[0069] Above eight flavors, get Corydalis Corydalis, rhubarb appropriate pulverization, make solvent with 60% ethanol, carry out percolation according to flow extract and extract item (Chinese Pharmacopoeia 2005 edition one appendix 10) after soaking for 24 hours, collect percolation liquid, Concentrate below 70°C; decoct dandelion and desmodium with water twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1.5 hours; filter, concentrate the filtrate and add Concentrate the above concentrated solution into a thick paste, dry and powder; then mix with artificial bezoar, silymarin, berberine hydrochloride and dextrin in appropriate amount, mix evenly, granulate, dry, spray peppermint oil, add magnesium stearate 2.5 g, mixed even...

Embodiment 3

[0071] Artificial bezoar 30g Silymarin 17.5g Berberine hydrochloride 12.5g Corydalis 125g

[0072] Rhubarb 12.5g Dandelion 150g Desmodium 200g Peppermint Oil 2g

[0073] Above eight flavors, get Corydalis Corydalis, rhubarb appropriate pulverization, make solvent with 60% ethanol, carry out percolation according to flow extract and extract item (Chinese Pharmacopoeia 2005 edition one appendix 10) after soaking for 24 hours, collect percolation liquid, Concentrate below 70°C; add water to decoct dandelion and desmodium 4 times, each time add 8 times the amount of water to decoct for 1 hour, filter, add the filtrate to the above concentrated solution to concentrate into a thick paste, dry and powder ; then mix with artificial bezoar, silymarin, berberine hydrochloride and lactose in appropriate amount, mix evenly, granulate, dry, spray into peppermint oil, add 5g of talcum powder, mix evenly, pack into capsules, make 1000 grains, and get ready.

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Abstract

A Chinese medicine for treating hepatobiliary diseases, such as acute or chronic cholecystitis, biliary tract infection and cholelithiasis, is prepared from 8 raw materials including artificial bezoar, silymarinum, rhubarb, dandelion herb, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for liver and gallbladder diseases and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. technical background [0002] Cholelithiasis such as gallstone, cholecystitis is present frequently-occurring disease, commonly encountered diseases, and often accompanying takes place, is one of common frequently-occurring diseases in my country. With the improvement of people's living standards, the proportion of high-cholesterol food intake in the diet has increased significantly. The increase in the concentration of cholesterol in the bile or the state of supersaturation makes cholesterol easy to precipitate and form stones, so the incidence of cholecystitis and gallstones continues to rise. the trend of. According to relevant data, the incidence rate of cholelithiasis in the natural population of my country is 1%-10%. As the age increases, the i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K9/48A61P1/16A61K31/4375A61K31/357A61K35/413
Inventor 张保献
Owner BEIJING YINKERUISI BIOLOGICAL PODUCTS RES INST
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