Recombinant newcastle disease virus
A technology of virus and RNA virus, applied in the fields of DNA, paramyxovirus, prevention or treatment of tumor diseases, cancer treatment, negative-strand RNA virus, Newcastle disease virus, and genetically processed viruses, can solve problems such as not being constructed
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[0020] Virus
[0021] The present invention relates generally to RNA viruses, preferably negative-strand RNA viruses, and more preferably to those viruses which have oncolytic properties and which can be genetically engineered. These viruses are:
[0022] - Paramyxovirus, preferably Newcastle disease virus (NDV), measles virus, mumps virus, Sendai virus;
[0023] - an orthomyxovirus, preferably an influenza virus;
[0024] - a baculovirus, preferably a vesicular stomatitis virus.
[0025] The subject of the present invention is therefore a recombinant oncolytic RNA virus comprising a nucleic acid with at least one transgene encoding a binding protein that is therapeutically active when expressed by virus-infected tumor cells .
[0026] Another subject of the present invention is a recombinant oncolytic RNA virus comprising a nucleic acid with at least one transgene encoding a prodrug converting enzyme expressed by tumor cells infected with the virus When it is therapeutic...
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