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Method for preparing lyophiled powder injection of bear bile for cooling and the function thereof

A technology of bear bile powder and prescription, which is applied in the field of preparation and application of antipyretic freeze-dried powder of bear bile for injection, and can solve problems such as inconvenience of oral administration, flammability and explosion of petroleum ether, difficulty of petroleum ether, etc.

Inactive Publication Date: 2007-10-31
成都尚科药业有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is very inconvenient for patients with febrile convulsions, especially children, to take oral administration in clinical practice, and intravenous administration has a rapid onset of action and high bioavailability
In the previous patents of freeze-dried powder of bear bile, most of the patents used petroleum ether to extract and remove impurities, but this method has obvious defects compared with modern resin adsorption methods: petroleum ether is flammable and explosive, and the cost of workshop protection and procurement is high. Difficulty in removing petroleum ether

Method used

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Examples

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Comparison scheme
Effect test

Embodiment

[0009] Example prescription: prescription: bear bile powder 0.015~1g / day / person, add a small amount of auxiliary materials such as mannitol, sodium hydroxide in addition, make 1000

[0010] Preparation method: heat and dissolve bear bile powder with appropriate amount of water, filter to obtain bear bile or bear bile powder aqueous solution, pass pretreated D 101 Macroporous adsorption resin column, add water to elute, then elute with 10-95% ethanol, collect ethanol eluate with different concentrations, recover ethanol under reduced pressure and concentrate to a clear paste with a relative density of about 1.08-1.12 (60°C), Spray-dried to obtain bear bile powder extract. Get the bear bile powder extract and mannitol of prescription quantity, dissolve in 1600ml water for injection, stir to dissolve, add 2mol / L sodium hydroxide to adjust the pH value to 7.2, add water for injection to full amount. Add appropriate amount of activated carbon for adsorption, decarburization, filte...

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PUM

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Abstract

The invention discloses a preparing method, which comprises the following steps: adding water into bear gall; heating; dissolving; adding water to elution with pre-treating resin; eluting with alcohol; collecting alcohol eluent; decompressing; reclaiming alcohol; condensing; spray-drying; or decompressing; vacuum-drying; getting the bear gall powder extract; adding into mannite; dissolving into water for injection; adjusting pH value to 5. 0-7. 2 with caustic soda; adsorbing with active carbon; decarbonizing; filtering with asepsis microporous filtering film; checking content; split-charging. This invention can be used to cure wind-heat lung heat and hyperpyretic convulsion.

Description

[0001] Field of Technology Pharmaceutical Technology Background technique [0002] Wind-warm lung-heat is equivalent to acute pneumonia and acute bronchitis in modern medicine, with a high incidence and great harm. Traditional Chinese medicine is accustomed to taking bear bile orally for patients with febrile convulsions in the treatment of wind-warm lung-heat, and the clinical effect is remarkable. However, it is very inconvenient for patients with febrile convulsions in clinical practice, especially children, to take oral administration, and intravenous administration has a quick effect and high bioavailability. In the previous patents of bear bile freeze-dried powder, most of the patents used petroleum ether to extract and remove impurities, but this method has obvious defects compared with modern resin adsorption methods: petroleum ether is flammable and explosive, and the cost of workshop protection and procurement is high. It is difficult to remove petroleum ether. Co...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61K9/14A61P11/00
Inventor 安世强牛锐
Owner 成都尚科药业有限公司