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Composition containing phosphorylcholine and preparing method thereof

一种磷酰胆碱、甘油磷酰胆碱的技术，应用在含磷酰胆碱基的化合物领域，能够解决反应收率低、目标磷酰胆碱化合物纯化步骤繁杂、纯化困难等问题

Active Publication Date: 2007-10-31
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The purification steps of the target phosphorylcholine compound are complicated and the purification is extremely difficult
The reaction yield is also low
[0017] In addition, if an organic solvent is used in the reaction solvent, the purification of the reaction solvent (removal of water) must be strictly carried out, and there are also environmental problems associated with the use of the organic solvent.
[0018] As mentioned above, the conventional preparation method of phosphorylcholine compound using phosphoryl chloride as a starting material still has many problems as an industrial preparation method.

Method used

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  • Composition containing phosphorylcholine and preparing method thereof
  • Composition containing phosphorylcholine and preparing method thereof
  • Composition containing phosphorylcholine and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0097] The present invention will be described in detail by way of examples below.

[0098] "Materials used"

[0099] The raw materials used in the production methods described below are commercially available items described below.

[0100] Glycerophosphorylcholine (prepared by Chemi Company)

[0101] Acetonitrile (Wako Pure Chemical Industries, Ltd., reagent special grade)

[0102] Sodium periodate (Wako Pure Chemical Industries, Ltd., reagent special grade)

[0103] Ruthenium trichloride n-hydrate (Wako Pure Chemical Industries, Ltd., reagent grade)

[0104] Hexaamine ruthenium dichloride (manufactured by Aldrich Co.)

[0105] Potassium permanganate (Wako Pure Chemical Industries, Ltd., reagent special grade)

[0106] "Preparation method 1: A preparation method using a trivalent ruthenium compound (claim 2)"

[0107] In a 200ml flask, add 5g (19.4mmol) glycerol phosphorylcholine, 17g (79.7mmol, 4.1eq) sodium periodate, 81mg (0.39mmol, 0.02mol%) ruthenium trichloride n...

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Abstract

The present invention is a phosphorylcholine-containing chemical compound represented by the following formula (1) or (2). (CH 3 ) 3 N + CH 2 CH 2 PO 4 - CH 2 COOH (1) (CH 3 ) 3 N + CH 2 CH 2 PO 4 - CH 2 COONa (2) The object of the present invention is to provide a new phosphorylcholine-containing compound that is useful as a surface treatment agent or a source material of a surface treatment agent. Another object is to provide a manufacturing method that has a high industrial utility value.

Description

technical field [0001] The invention relates to compounds containing phosphorylcholine groups and their preparation methods. [0002] The phosphorylcholine group-containing compound of the present invention is a compound that can be used as a surface treatment agent for various materials such as plastics, metals, and glass, or as a raw material for a surface treatment agent. [0003] The surface modifier containing the compound of the present invention can impart biocompatibility, moisture retention, hydrophilicity and other various useful functions to objects. Background technique [0004] Phosphorylcholine group-containing compounds are used as surface treatment agents for improving biocompatibility and the like. For example, in Patent Document 1, in order to reduce protein and cell precipitation, it can be used as a surface treatment agent for diagnostic devices or contact lenses. [0005] In Patent Document 1, the phosphorylcholine group-containing compound used as a s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/09C09K3/00
CPCC07F9/091C07F9/09C07F1/04C07F9/02
Inventor 隅田如光宫泽和之
Owner SHISEIDO CO LTD