Skeleton medicine rubber stopper and its making process

Abstract

The present invention is one kind of medicinal rubber stopper with skeleton and its making process. The medicinal rubber stopper has a stopper skeleton coated with medicinal elastic material. It is made through one of three making processes, plate molding and vulcanizing process, one-step plate molding and vulcanizing process and injection molding process. The medicinal rubber stopper with skeleton has the advantages of high rubber content, high sealing performance, low cost, high hardness, high needle prick resistance, high heat resistance, etc.

Description

technical field [0001] The invention relates to a medicinal rubber stopper, in particular to a medicinal rubber stopper comprising a skeleton plug. Background technique [0002] With its unique chemical stability, excellent sealing and self-sealing properties, and high-temperature disinfection performance, medicinal corks provide a guarantee for the preservation of pharmaceutical packaging. However, rubber has no elasticity, only plasticity, and is easy to be molded into any shape. In order to endow medical rubber stoppers with suitable physical properties such as hardness, strength and tear strength, and meet the requirements of pharmaceutical production and clinical use, an appropriate amount must be added to its main material. Additives and fillers based on inorganic materials are of value only after vulcanization process hardens to form cork products. Such substances account for about 50% of the overall formula. The national standard stipulates that it should not exceed...

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Problems solved by technology

[0003] During the implementation of the national trial standard, it was found that due to better control of the content of residue on ignition, although the content of medicinal rubber has increased relatively, the hardness of the rubber stopper will decrease accordingly. On the one hand, it has caused pharmaceutical companies to use During the process, the probability of putting the rubber stopper on is reduced. On the other hand, if the drug is not properly punctured during clinical use, the rubber stopper can easily be inserted into the bottle.

As far as the performance of the rubber stopper is concerned, the hardness is an important control item that cannot be ignored. If the hardness of the rubber stopper is too low, the rubber stopper is easily deformed by the internal pressure during steam sterilization in the pharmaceutical factory, and the chance of sealing is reduced during use, which affects production efficiency and The sterility of the product is guaranteed. In addition, when the injection needle is inserted into the rubber stopper in clinical use, the rubber stopper is also easy to be pushed into the bottle; if the hardness is too high, a lot of force is required when the injection needle is inserted, which is not easy to operate, and at the same time, the puncture debris will also be obvious increase, and will reduce the airtight self-sealing performance of the rubber plug

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