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Compsoite vitamin injection and its production

A technology of complex vitamins and injections, which is applied in the field of medicine, and can solve problems such as the formation of suspensions or precipitation, and easy turbidity

Inactive Publication Date: 2007-11-21
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when simple fat-soluble or water-soluble injections are used in the treatment of patients with vitamin deficiency and parenteral nutrition, turbidity, suspension or precipitation are likely to occur during mixed use.
And the injection prepared by mixing and dissolving fat-soluble and water-soluble vitamins has not been reported, especially the preparation with 13 kinds of various vitamins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Prescription and preparation method of the first bottle of injection for adults:

[0017] prescription:

[0018] VitC 400g

[0019] VitA 6.6 million IU

[0020] VitD 3 3.4 million IU

[0021] VitB 1 12g

[0022] Vit B 2 7.2g

[0023] VitB 6 12g

[0024] Niacinamide 80g

[0025] Dexpanthenol 30g

[0026] VitE 20,000 IU

[0027] VitK 0.3g

[0028] Tween-80 140g

[0029] EDTA CaNa 2 5g

[0030] BHA 1g

[0031] Sodium metabisulfite 1g

[0032] Appropriate amount of sodium hydroxide

[0033] Add water for injection to 10000ml

[0034] Made: 2000 pieces

[0035] Preparation:

[0036] 1. Dissolving fat-soluble vitamins

[0037] Take Tween-80 and add the prescribed amount of BHA, vitamin A (palmitate), vitamin E, vitamin K, and vitamin D in sequence 3 , heated in a water bath to 60°C and stirred to dissolve completely, and kept warm.

[0038] 2. Dis...

Embodiment 2

[0049] Prescription and preparation method of the second bottle of injection for children:

[0050] prescription

[0051] Folic Acid 1.4g

[0052] Vitamin H 0.2g

[0053] Vitamin B 12 0.01g

[0054] Trisodium Citrate Appropriate amount

[0055] Add water for injection to 10000ml

[0056] Preparation:

[0057] 1. Take folic acid, add it to about 3000ml water for injection, add an appropriate amount of trisodium citrate, adjust the pH to about 7.0, heat and stir to dissolve completely. join in

[0058] 2. Take vitamin H and vitamin B 12 Add to about 1000ml water for injection, heat and stir to dissolve.

[0059] 3. Mix the two liquids, add 0.05% g needle and stir well with activated carbon, heat in a water bath at 60°C for 15 minutes, decarbonize while it is hot, constant volume, filter with a 0.22μm microporous membrane, bottle it after passing the inspection, and sterilize.

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PUM

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Abstract

The invention is concerned with compound vitamin injecting liquid and its produce method. This injecting liquid relates compound vitamin for adult and children and made of two bottles. The first bottle has vitamin C, vitamin A, vitamin D3, vitamin B1, vitamin B2, vitamin B6, niacinamide, dextrorotation panthenol, vitamin E, vitamin K and proper hydrotropic agent. The second bottle has folic acid, vitamin H and vitamin B12. The injecting liquid has same component in different dosage. The production is water-solubility injection with nice stability and safety. It can be diluted as common vitamin maintain agent. It can be used in vein for some conditions. The conditions relate to surgical, burn with large range, fracture and other trauma, serious infection illness and narcosis. Those conditions change the demand greatly and consume nutrition.

Description

technical field [0001] The invention relates to a preparation for parenteral nutrition administration as a daily vitamin maintenance agent and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Vitamins can be divided into water-soluble and fat-soluble according to their solubility. Water-soluble vitamins include vitamin B and vitamin C, and fat-soluble vitamins include vitamins A, D, E, and K. They maintain the normal physiological function and material energy metabolism of the human body, and are one of the important nutritional elements for the human body. [0003] At present, there are many kinds of preparations of vitamin drugs, but most of them are taken orally, and there are few preparations available for injection. Among them, the compound vitamins available for intravenous injection include compound fat-soluble vitamin preparations, such as fat emulsions and compound water-soluble vitamin preparations. Howeve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/51A61K31/525A61K31/4415A61K31/375A61K31/355A61K31/455A61K31/593A61K31/07A61K31/122A61K9/08A61P3/02
Inventor 路洪书
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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