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Composition for treating angitis, preparation and its preparation method

A composition and technology for vasculitis, applied in the field of effective site compositions, can solve the problems of color change of injection, incomplete removal of tannin, influence on the safety and effectiveness of Mailuoning injection, etc.

Inactive Publication Date: 2011-10-26
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing preparation process of Mailuoning injection adopts water extraction and alcohol precipitation method to extract four medicinal materials simultaneously, and then extracts the active ingredient with ethyl acetate (see "Technical method of Mailuoning injection", publication number CN1078148A) However, the prescription contains chlorogenic acid and other components that are unstable to light and air, and the color change of the injection solution and the content of active ingredients are prone to decrease during storage. The prescription contains organic acids and alkaloids, etc. These components are prone to flocculation and precipitation in the needle state. At the same time, this method does not completely remove tannins, which seriously affects the safety and effectiveness of clinical application of Mailuoning Injection.

Method used

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  • Composition for treating angitis, preparation and its preparation method
  • Composition for treating angitis, preparation and its preparation method
  • Composition for treating angitis, preparation and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Preparation and assay of the extract of embodiment 1

[0120] Extract preparation

[0121] (1) Take 5000g Dendrobium, 5000g Scrophulariaceae, and 5000g Achyranthes bidentata and grind them into coarse powder, add water to soak, heat and reflux to extract twice, add 8 times the amount of water for the first time, add 6 times the amount of water for the second time, each time for 2 hours, Filter, combine the filtrates, concentrate under reduced pressure to a relative density of 1.15 (50°C), add ethanol to make the alcohol content reach 60%, refrigerate, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.15 (50°C), add ethanol to make the alcohol content reach 60%. The alcohol content reaches 80%, refrigerated, filtered, and the filtrate is decompressed to recover ethanol and concentrated to no alcohol smell, diluted with water, refrigerated overnight, and filtered to obtain filtrate A;

[0122] (2) Add hydrochloric acid to ethanol, adj...

Embodiment 2

[0139] The preparation of embodiment 2 extract

[0140] (1) Take 5000g Dendrobium, 5000g Scrophulariaceae, and 5000g Achyranthes bidentata and grind them into coarse powder, add water to soak, heat and reflux to extract twice, add 10 times the amount of water for the first time, add 6 times the amount of water for the second time, each time for 2 hours, Filter, combine the filtrates, concentrate under reduced pressure to a relative density of 1.15 (50°C), add ethanol to make the alcohol content reach 50%, refrigerate, filter, concentrate the filtrate under reduced pressure to a relative density of 1.15 (50°C), add ethanol to make the alcohol content reach 50%. The alcohol content reaches 70%, refrigerated, filtered, and the filtrate is decompressed to recover ethanol and concentrated to no alcohol smell, diluted with water, refrigerated overnight, and filtered to obtain filtrate A;

[0141] (2) Add hydrochloric acid to ethanol, adjust the pH value of ethanol to 3-5, 5000g hone...

Embodiment 3

[0143] The preparation of embodiment 3 extract

[0144] (1) Take 8000g Dendrobium, 2000g Scrophulariaceae, and 4000g Achyranthes bidentata and grind them into coarse powder, add water to soak, heat and reflux to extract twice, add 8 times the amount of water for the first time, add 8 times the amount of water for the second time, each time for 2 hours, Filter, combine the filtrates, concentrate under reduced pressure to a relative density of 1.15 (50°C), add ethanol to make the alcohol content reach 70%, refrigerate, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.15 (50°C), add ethanol to make the alcohol content reach 70%. The alcohol content reaches 85%, refrigerated, filtered, and the filtrate is decompressed to recover ethanol and concentrated to no alcohol smell, diluted with water, refrigerated overnight, and filtered to obtain filtrate A;

[0145] (2) Add hydrochloric acid to ethanol, adjust the pH value of ethanol to 3-5, 6000g h...

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Abstract

The invention relates to a medicinal composition for treating vasculitis, preparation and the process for preparing same, wherein the preparing process comprises the steps of extracting achyranthes and cyathula root, scrophularia root and Dendrobium nobile with water, alcohol depositing twice, water depositing, filtering, obtaining filtrate A, subjecting honeysuckle flower herb to ethanol extraction and water deposition, adjusting pH of the filtrate, passing through macroscopic adsorption resin column, eluting with water, concentrating the eluent, filtering, obtaining filtrate B, merging A and B, filtering and concentrating the filtrate. the composition of the invention can be used as active constituent to obtain any of the pharmacologically acceptable dose forms by charging pharmaceutically acceptable auxiliary materials.

Description

technical field [0001] The invention relates to an effective site composition, in particular to a composition for treating vasculitis, a preparation and a preparation method thereof. Background technique [0002] Mailuoning Injection is a traditional Chinese medicine compound injection developed on the basis of the famous medical prescription "Simiao Yong'an Decoction". inflammation, arteriosclerotic obliterans, cerebral thrombosis and sequelae, Takayasu arteritis, acute arterial embolism of extremities, diabetic gangrene, venous thrombosis and thrombophlebitis, etc. Chinese patent CN1557398A discloses that it also has the effect of preventing and treating angina pectoris. However, the existing preparation process of Mailuoning injection adopts water extraction and alcohol precipitation method to extract four medicinal materials simultaneously, and then extracts the active ingredient with ethyl acetate (see "Technical method of Mailuoning injection", publication number CN10...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61P9/14
Inventor 宋兆辉叶正良郑永锋白雨
Owner TIANJIN TASLY ZHIJIAO PHARMA