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Biochip hybridization procedure optimization control method and apparatus employing the method

A biochip and chip technology, applied in biochemical equipment and methods, biochemical cleaning devices, microbial measurement/inspection, etc., can solve the problems of long reaction time of hybridization solution, small number of hybridization chips, and large operator dependence , to achieve optimization of hybridization process, good vibration effect, friendly keyboard and display interface

Active Publication Date: 2007-12-12
北京和利康源医疗科技有限公司
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AI Technical Summary

Problems solved by technology

At present, there are many conventional biochip hybridization equipment, but there are usually the following problems: 1) Each step is carried out independently, and the waste liquid needs to be sucked away manually, which is highly dependent on the operator and cumbersome to operate; 2) The temperature is set in steps. 3) The number of chips that can be hybridized at the same time is small, and the efficiency is low; 4) The shaking effect is slow, the reaction time of the hybridization solution is long, and the efficiency is low

Method used

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  • Biochip hybridization procedure optimization control method and apparatus employing the method
  • Biochip hybridization procedure optimization control method and apparatus employing the method
  • Biochip hybridization procedure optimization control method and apparatus employing the method

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Embodiment Construction

[0031] As shown in FIG. 1 , the present invention includes: a hybridization chamber 1 , a rotating part 2 , a chip carrier 3 , a cleaning tube 4 , an operating part 5 , a main control part 6 , a cleaning part 7 and a casing 12 . The operation part 5 is arranged on the upper part of the casing 12, and it is mainly composed of a keyboard and a display screen. The hybridization chamber 1 is installed in the middle upper position of the casing 12, and the hybridization chamber 1 is provided with a chip carrier 3, on which the chip carrier 3 can place chip cassettes, and the chip carrier 3 can be designed to bear the structure of n chip cassettes, n The optimal choice is 18, and when the number of chip cassettes changes, only the area of ​​the chip carrier 3 needs to be changed. The chip carrier plate 3 is made of plastic, and a metal plate 13 which can control the temperature of the hybridization solution in the chip box is arranged on the bottom thereof, and the metal plate 13 is...

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Abstract

The invention discloses a kind of biological chip hybridisation machine, comprising hybridisation cavity, chip carrying disk, rotary part, temperature control part and master control part. The chip is installed in hybridisation cavity, chip carrying disk is drove by rotary part; rotary part is controlled by master part, the temperature inside hybridisation cavity is moderated by said temeprature control part. The invention aslo discloses an optimal method for controlling biological chip hybridisation process. It comprises following steps: (1) putting washing liquid into hybridisation cavity in advance, putting pre- hybrid biological chip box on chip carrying disk, rising temperature in hybridisation cavity through temperature part to proper temperature; (2) the rotary vibration of chip carrying disk is drove by controlling rotary part according to set vibration index, (3) drying left hybridisation liquid by rotary part after hybridisation is over.

Description

technical field [0001] The invention relates to a biochip hybridization device and a biochip hybridization process optimization control method. Background technique [0002] Biochip technology can integrate various biochemical reaction processes in life science and medicine, so as to realize efficient and rapid testing and analysis of biologically active substances such as genes, ligands, and antigens. Its appearance has brought great innovations and even revolutions to many fields such as life sciences, medicine, chemistry, new drug development, biological warfare, judicial identification, food and environmental supervision. [0003] Hybridization-based analysis has been widely used in the research and application of gene mutation detection, polymorphism analysis, gene mapping, etc. The hybridization instrument is a device specially used to complete the hybridization process of biochips. For biochips: pre-hybridization, hybridization, washing, blocking, enzyme-linked, colo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M1/36C12Q1/68
Inventor 王常力周骋刘旭青史洪源
Owner 北京和利康源医疗科技有限公司
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