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Composition of antihypertensive drug of compound pargyline

A composition and drug technology, which is applied in the direction of drug combination, sugar-coated pills, pharmaceutical formulas, etc., can solve the problems of not disclosing the ratio and specific dosage of pagiline and reserpine

Inactive Publication Date: 2007-12-26
中国人民解放军北京军区司令部第二离职干部休养所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application does not disclose the ratio and specific dosage of pagiline and reserpine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 tablet

[0020] The specific composition of the tablet is as follows:

[0021] Pagiline Hydrochloride (Youjiangning) 1.25Kg

[0022] Reserpine 0.015Kg

[0023] Powdered sugar 24.0Kg

[0024] Starch 31.44Kg

[0025] Dextrin 4.0Kg

[0026] Magnesium Stearate 0.7Kg

[0027]

[0028] Made 1,000,000 pieces

[0029] The preparation steps are as follows:

[0030] 1. Ingredients

[0031] 1. Accurately take the active component raw material (hereinafter referred to as main ingredient) by formula, all pass through 80 mesh sieves.

[0032] 2. Put all the raw materials of active ingredients in a stainless steel mixer and mix them evenly.

[0033] 4. Take out the evenly mixed active ingredients and set aside.

[0034] 5. Prepare auxiliary materials according to the formula: first put 31.5kg of medicinal starch passed through a 100-mesh sieve into a stainless steel mixer, then add 24Kg of powdered sugar passed through an 80...

Embodiment 2

[0043] Embodiment 2, coated tablet

[0044] 1,000,000 tablets prepared in Example 1 are coated according to the following steps:

[0045] 1. Preparation of coating slurry: prepare 20 kg of 70% syrup, and 14 kg of talcum powder to prepare a slurry.

[0046] 2. Preheat the bottom of the coating pan.

[0047] 3. Wrap the isolation layer: put on the film, sprinkle with 1000ml syrup, stir quickly, sprinkle an appropriate amount of talcum powder, stir evenly, and blow dry, four times in total.

[0048] 4. Powder coating layer: Add 1000ml of powder slurry into the coating pan, stir evenly, roll, and then blow dry.

[0049] 5. Sugar coating layer.

[0050] 6. Lighting.

Embodiment 3

[0051] Example 3 tablet

[0052] According to the method for embodiment 1, prepare the tablet that forms as follows:

[0053] Pagiline Hydrochloride (Youjiangning) 1.25kg

[0054] Reserpine 0.015kg

[0055] Dihydralazine Sulfate 0.625kg

[0056]Hydrochlorothiazide 1.25kg

[0057] Powdered sugar 24.0kg

[0058] Starch 31.44kg

[0059] Dextrin 4.0kg

[0060] Magnesium stearate 0.7kg

[0061]

[0062] Made 1,000,000 pieces

[0063] Above-mentioned tablet can carry out coating according to the method for embodiment 2.

[0064] Example 3 tablet

[0065] According to the method for embodiment 1, prepare the tablet that forms as follows:

[0066] Pagiline Hydrochloride (Youjiangning) 1.25kg

[0067] Reserpine 0.015kg

[0068] Dihydralazine Sulfate 0.625kg

[0069] Hydrochlorothiazide 1.25kg

[0070] Rutin 1.0kg

[0071] Powdered sugar 24.0kg

[0072] Starch 31.44kg

[0073] Dextrin 4.0kg

[0074] Magnesium stearate 0.7kg ...

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PUM

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Abstract

The present invention relates to a medicine for curing hypertension. In the concrete, it relates to a pargyline compound medicine composite. Said pargyline compound medicine composite can obtain obvious therapeutic effect for curing primary hypertension.

Description

technical field [0001] The present invention relates to a medicine for treating hypertension, in particular the present invention relates to Pajilin compound pharmaceutical composition. Through the observation of clinical case data, it has achieved remarkable curative effect on the treatment of middle-aged and elderly patients with essential hypertension, and is highly trusted by the majority of hypertensive patients. Background of the invention [0002] Due to increased work pressure, irregular life, bad eating habits, genetics and other factors, high blood pressure is a common disease, especially for middle-aged and elderly people. Statistics released by the Ministry of Health show that there are more than 100 million hypertensive patients in my country, and the number of people is increasing at a rate of more than 3 million each year. The mortality rate of cardiovascular and cerebrovascular complications due to hypertension has risen from 10.07% in 1957 to more than 40% ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/475A61K31/549A61K31/519A61K31/5513A61K31/7048A61K9/20A61K9/28A61K9/48A61K9/14A61K9/12A61P9/12A61K31/137A61K31/502A61K31/4184A61K31/5415
Inventor 翟寅玲
Owner 中国人民解放军北京军区司令部第二离职干部休养所