Pargyline and asarum oil nanoemulsion antihypertensive medicine

Abstract

The invention discloses an oil-in-water type pargyline and asarum oil nanoemulsion antihypertensive medicine and a method for preparing the same. The nanoemulsion antihypertensive medicine is characterized in that the grain size of the nanoemulsion antihypertensive medicine is between 22.2-60.1 nanometers, and the mean grain size is 39.2 nanometers. The nanoemulsion antihypertensive medicine comprises the following raw materials by mass percent: 1%-18% of pargyline, 15%-40% of surfactant, 1%-25% of cosurfactant, 1%-20% of asarum and the balanced of distilled water. The nanoemulsion has small emulsion droplet particles, uniform distribution, small viscosity and good liquidity. The nanoemulsion organically combines the water-soluble medicine pargyline and the fat-soluble asarum oil together, so the dissolution and infiltration capacities of the asarum oil are improved, and the stability and pharmaceutical effect of the pargyline are enhanced. After the pargyline and the asarum oil are prepared into the nanoemulsion, the advantages of the pargyline and the asarum oil are combined together, so the antihypertensive effect is obviously improved, the pharmaceutical half-life period of the antihypertensive medicine is prolonged, and the medicine administration times are reduced.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of antihypertensive drug pajilin and asarum oil, in particular to a nanoemulsion antihypertensive drug of pajiline and asarum oil. [0002] Background technique [0002] Pargyline is a white crystalline powder with a specific odor. soluble in water. It has obvious antihypertensive effect, and is currently the only antihypertensive drug used among monoamine oxidase inhibitors. Its antihypertensive mechanism may be due to the inhibition of monoamine oxidase, which changes the normal metabolism of tyramine in adrenergic nerve endings. Produces beta-hydroxytyramine, a "pseudomediator" that, like norepinephrine, is stored, released, and binds to receptors, but does not act as a postganglionic sympathetic impulse because it elicits a weaker response conduction, resulting in vasodilation and a drop in blood pressure. The racemic higenamine in asarum has a wide range of phar...

AI Technical Summary

Problems solved by technology

Existing antihypertensive drugs such as Pajilin tablets on the market now also have the use of asarum oil, although they can be absorbed from the gastrointestinal tract after oral administration, the absorption is not complete, and the dissolution rate of the medicine is slow in addition, and the bioavailability is poor. Pajilin acts slowly, so that the efficacy of Pajilin and asarum oil cannot be fully utilized