Blood pressue lowering sustained-release preparation with chrysanthemum flower and pearl

A technology of sustained-release preparations and sustained-release pellets, which can be applied to medical preparations containing active ingredients, plant raw materials, cardiovascular system diseases, etc., and can solve problems such as complex chemical components and huge differences in physical and chemical properties

Inactive Publication Date: 2008-01-09
上海雷允上科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on compound sustained-release preparations has not made breakthroughs. The main reason is that the chemical components in compound Chinese medicine are quite complex, and the physical and chemical properties of each component are greatly different. How to make the chemical components with different properties achieve simultaneous release while slow release , and how to make a more comprehensive evaluation of it in vivo and in vitro has become a difficulty and hot spot in the study of compound Chinese medicine sustained-release preparations

Method used

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  • Blood pressue lowering sustained-release preparation with chrysanthemum flower and pearl
  • Blood pressue lowering sustained-release preparation with chrysanthemum flower and pearl
  • Blood pressue lowering sustained-release preparation with chrysanthemum flower and pearl

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1: the preparation of wild chrysanthemum pellets

[0073] Prescription (percentage by weight):

[0074] Blank Cellulose Ball Core 40%

[0075] Wild Chrysanthemum Extract 55%

[0076] Polyvinylpyrrolidone (PVP K30) 2%

[0077] Silica 3%

[0078] Preparation method: 1 / 3 of the prescription amount of wild chrysanthemum extract and blank ball cores are placed in a coating pan, and 1 / 2 of the prescription amount of silicon dioxide is added at the same time to prepare a 70% ethanol solution of polyvinylpyrrolidone, and the polyethylene is sprayed with a spray gun. Spray the 70% ethanol solution of pyrrolidone onto the pellets, and at the same time gradually sprinkle the remaining wild chrysanthemum extract and silicon dioxide, repeat this process to form moderately sized pellets, sieve to remove the sticky pellets, and obtain the wild chrysanthemum pellets.

Embodiment 2

[0079] Embodiment 2: the preparation of wild chrysanthemum pellets

[0080] Prescription (percentage by weight):

[0081] Wild Chrysanthemum Extract 85%

[0082] Microcrystalline Cellulose 5%

[0083] Ethylcellulose 5%

[0084] Micronized silica gel 5%

[0085] Preparation method: prepare ethyl cellulose ethanol solution, mix the wild chrysanthemum extract, microcrystalline cellulose, and micropowder silica gel in the prescription evenly, spray into ethyl cellulose ethanol solution to make soft material, extrude, pass through the net The hole forms a cylindrical strip, and the strip-shaped material is placed on the centrifugal turntable in the rotating bed. The high-speed rotation of the turntable makes the material form a circular spiral motion along the wall. The rotating bed rotates at a speed of 8-26 rpm. Spray an appropriate amount of distilled water, and the materials will continue to roll and further bond to form microspheres, which will become moderately sized micr...

Embodiment 3

[0086] Embodiment 3: the preparation of wild chrysanthemum pellet

[0087] Prescription (percentage by weight):

[0088] Blank starch pellet core 29%

[0089] Wild Chrysanthemum Extract 60%

[0090] Microcrystalline Cellulose 5%

[0091] Acrylic resin (RS100) 3%

[0092] Magnesium Stearate 3%

[0093] Preparation method: take the wild chrysanthemum extract and the blank ball core in the prescription and place them in a fluidized bed, add microcrystalline cellulose and magnesium stearate at the same time, prepare a 50% ethanol solution of acrylic resin, and spray the 50% ethanol solution of acrylic resin with a spray gun To the material in the fluidized bed, the inlet air temperature is controlled at 50-60°C, the relative humidity of the inlet airflow is 40-70%, and the atomization pressure is 2-4bar, until the particle size of the pellets in the fluidized bed is 0.3 mm ~ 0.9mm. Sieve to remove the sticky pellets to obtain wild chrysanthemum pellets.

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Abstract

The present invention discloses a Zhenju Jiangya slow release preparation for stably reducing blood pressure. It is a Chinese medicine and Western medicine combined compound slow release preparation made up by using hydrochlorothiazide, clonidine hydrochloride, wild chrysanthemum flower extract, pearl layer powder and sophora flower extract through a certain preparation process. Said invention also provides the concrete steps of its preparation process.

Description

technical field [0001] The invention relates to a compound preparation of traditional Chinese and western medicines, in particular to a Zhenju Jiangya slow-release preparation prepared by making the active ingredient in the existing Zhenju Jiangya tablet into a sustained-release preparation. Background technique [0002] The active ingredients of Zhenju Jiangya Tablets are composed of traditional Chinese medicine wild chrysanthemum extract (referred to as wild chrysanthemum), nacre powder, sophora japonica extract (rutin), western medicine clonidine, and hydrochlorothiazide. Lower blood pressure, nacre powder can nourish the heart and calm the nerves, the adjuvant clonidine hydrochloride has a central blood pressure lowering effect, rutin can reduce capillary permeability and increase its tension, hydrochlorothiazide is a diuretic and antihypertensive drug, all drugs combined have antihypertensive effect It can not only reduce blood pressure, but also improve various clinica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/22A61P9/12A61K35/56A61K31/549A61K31/4166A61K35/618
Inventor 樊敏伟王建新谢家骏周国伟宋英宋崎乔正东
Owner 上海雷允上科技发展有限公司
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