**TC*N nucleus marked dithiocarbamate complex, preparing method and application of the same

Abstract

The invention discloses a dithiocarbamate complex marked by a kind of 99TcmN nuclear with general formaul as 99TcmN (DTC) 2, which is blended by five dithiocarbamate complexes marked by 99TcmN (DTC)2 with 99TcmN(3M2BDTC)2, 99TcmN(DEDTC)2, 99TcmN(4MCHDTC)2, 99TcmN(NMCHDTC)2 and 99TcmN(CHDTC)2 according to freeze-drying method, wherein the complex has good external stability under indoor temperature with radioactive chemical purity over 90%, which can be tumour imaging agent with applying value in the nuclear medical and radioactive drug chemical domain. The invention can be widely applied in the development of human or animal organ tissue, especially for the application of tumour development.

Description

Technical field [0001] The invention relates to 99 Tc m N-labeled radiopharmaceutical chemistry and clinical nuclear medicine technology fields, specifically related to a class 99 Tc m N-nucleus-labeled dithiocarbamate complex, its preparation method and application, especially 99 Tc m The application of N-core labeled dithiocarbamate complex as a tumor imaging agent in human or animal organs or tissues. Background technique [0002] Tumors are one of the diseases that seriously threaten human life. Imaging medical examinations provide a reliable non-invasive means for tumors. Nuclear medicine imaging has improved from pure anatomical information to functional metabolism and other information, creating better early diagnosis. condition. In terms of imaging, due to 99 Tc m It has short half-life (6.02 hours), suitable γ-ray energy (140 kiloelectron volts), and can be easily obtained from the molybdenum technetium generator. Therefore, 99 Tc m Become the first choice for radiopharm...

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Problems solved by technology

[0004] It plays a greater role in the diagnosis and research of lung cancer, breast cancer, thyroid cancer and other diseases, but its target / non-target ratio is low, the imaging time is long, and the sensitivity and specificity of some tumor diagnoses need to be improved.

Apart from 99 TC m -In addition to MIBI, there are currently 99 Tc m N-labeled aminocarbamate complexes 99 Tc m N(CPEDTC) 2 (CPEDTC: Cyclopentylcarbamate) in vitro for the application of breast cancer imaging research, such as Chinese patents; patent publication number: CN1786009; patent name: 99 Tc m N(CPEDTC) 2 The application of complexes in the field of tumor imaging, 99 Tc m N(CPEDTC) 2 The complex has a high uptake in tumors, but the ratios of tumor / muscle and tumor / blood still need to be improved

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