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Application of fevervine iridoid glycosides and its preparation

A technology of iridoids and sagebrush is applied in the field of medicinal use of active ingredients of traditional Chinese medicines, and can solve the problems of low curative effect, large side effects and the like.

Inactive Publication Date: 2008-04-09
周兰兰
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AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide the application and preparation of the total iridoid glycosides of the genus vine, use the total iridoid glycosides of the genus vine to prepare analgesics and anti-inflammatory drugs, overcome the shortcomings of western medicines such as low curative effect and large side effects, Provide active ingredients extracted from single traditional Chinese medicine with few side effects as an ideal analgesic and anti-inflammatory drug

Method used

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Embodiment Construction

[0016] The following biological activity experiment is a further detailed description of the present invention, but does not mean any limitation to the present invention.

[0017] Experiment 1. Effect of IGPS on writhing response induced by acetic acid

[0018] 1 Experimental materials

[0019] 1.1 Animal: Kunming mouse, ♀ Half and half, weighing 18-22g, all animals were purchased from the Animal Center of Anhui Medical University.

[0020] 1.2 Drugs: Iridoid Glycosides (IGPS), self-made. The positive drug, Naproxen Capsules, was produced by Hefei Jiulian Pharmaceutical Co., Ltd., batch number 20070101. When in use, distilled water was used to make suspensions of required concentrations for intragastric administration, while the control group was given the same volume of distilled water.

[0021] 2 Experimental methods and results

[0022] 55 mice were randomly divided into five groups: normal saline (NS) control group, naproxen positive drug group (25 mg / kg), IGPS 800, ...

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Abstract

The invention relates to the use of fevervine iridoid total glycoside or the composition of the effective component thereof in preparing medicines for treating pains and inflammation, and belongs to the field of the medical use of the effective component of Chinese medicine. The invention uses the fevervine iridoid total glycoside to prepare analgesics, overcomes disadvantages of strong side effects of the prior Western medicine therapy, etc., and provides the effective component extracted from a single medicine with little side effects as the ideal analgesics. The sources of the raw materials of the fevervine are rich, the invention develops the medicinal prospect for the fevervine iridoid total glycoside, and relative new medicine development can be performed on the basis of the invention.

Description

technical field [0001] The invention belongs to the field of medical application of active ingredients of traditional Chinese medicines, in particular to the application and preparation of total iridoid glycosides of the effective part of the vine vine, the vine vine. Background technique [0002] Pain is not only a common symptom of many diseases, but also a disease in itself. In addition to pain sensation, pain is often accompanied by emotional, cardiovascular and respiratory changes, and severe cases can lead to shock. Therefore, pain treatment is a major clinical problem at present. In addition to treating the primary disease, pain control is mainly based on drug therapy. At present, the commonly used analgesics are central analgesics and antipyretic analgesics. Central analgesics have strong analgesic effect, but they are addictive; effect, but the analgesic effect is weak, and there are side effects such as severe gastrointestinal toxicity. Therefore, finding an ana...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P29/00
Inventor 周兰兰马颖颜海燕刘梅
Owner 周兰兰
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