Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of iridoids compound in preparing medicine for treating benign prostate hyperplasia

A technology for iridoids and benign prostatic hyperplasia, which can be used in drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of affecting clinical and market promotion, high price, and restricting the use of the elderly.

Active Publication Date: 2008-04-30
成都草木金华科技有限公司
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcoming is that it has a certain impact on a small number of cardiovascular patients, which limits the use of some elderly people and affects clinical and marketing promotion.
[0009] Most of the above-mentioned drugs have certain toxic and side effects, and the price is relatively high.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of iridoids compound in preparing medicine for treating benign prostate hyperplasia
  • Application of iridoids compound in preparing medicine for treating benign prostate hyperplasia
  • Application of iridoids compound in preparing medicine for treating benign prostate hyperplasia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1 Preparation and structure identification of the compounds of the present invention

[0068] 1. Extraction and separation

[0069] Coarse rhizome powder (6kg) was extracted by percolation with 95% ethanol as solvent, and 30L of percolation solution was collected and concentrated under reduced pressure to obtain 1500g of total extract. The total extract was dispersed in 500ml of water, extracted with petroleum ether (60~90℃), ethyl acetate and n-butanol in turn, and the solvent was recovered under reduced pressure to obtain 290g of petroleum ether (60~90℃) extract, which was extracted with ethyl acetate 130g of extract, 200g of n-butanol extract. (1) Further separation of petroleum ether extract

[0070] 100 g of the petroleum ether (60-90° C.) extract was subjected to silica gel column chromatography (gradient elution of petroleum ether→petroleum ether / ethyl acetate→ethyl acetate→acetone), and crudely divided into 204 parts.

[0071] PE51 # ~65 # After the...

Embodiment 2

[0119] Example 2 Preparation of an anti-benign prostatic hyperplasia capsule:

[0120] Take 1 kg of compound A and 6 kg of compound B, add an appropriate amount of starch, mix evenly, dry granulate, and divide into capsules after granulating.

[0121] The beneficial effects of the present invention are demonstrated below by the activity test.

experiment example 2

[0125] Experimental Example 2 Compound B of the present invention (PE116 # ) on the inhibition of 5α-reductase activity. The experimental method is the same as that of Experimental Example 1.

[0126] T

sample

T+h-DMEM

0.1mM

Cells

Testosterone T

0.1mM

Compound B

100ug / ml

OD value

average

T(ng / ml)

2.184

2.077

2.130

5.014

2.156

2.169

2.162

4.695

2.187

2.196

2.192

4.421

2.056

1.970

2.013

6.383

[0127] DHT

sample

Cells

0.1mM

T

0.1mM

Compound B

100ug / ml

OD value

average

DHT(ng / ml)

1.603

1.656

1.629

1.009

1.029

1.098

1.064

5.405

1.207

1.200

1.203

3.572

[0128] The results show that the sample...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses the usage of iridoid compounds in preparing the drug for the treatment of benign prostatic phyperplasia. The compounds come from valerianaceae plants which have a long medical history and excellent safety. The drug-effect substance of the compounds is clearer than original spider fragrant plant extract. The invention makes the possibility for good market outlook of new anti benign prostatic phyperplasia medicament.

Description

technical field [0001] The invention relates to a new use of a class of compounds, in particular, to the use of iridoid compounds in the preparation of medicines for treating benign prostatic hyperplasia, which belongs to the field of medicine. Background technique [0002] With the acceleration of the aging process of society, the incidence of many diseases of the elderly is gradually increasing. Among them, male benign prostatic hyperplasia is one of the most common diseases. According to statistical analysis, patients with benign prostatic hyperplasia (BPH) account for about 20% of elderly men. The incidence of BPH is also related to ethnicity and region. The incidence of eastern people is lower than that of western ethnic groups. The incidence of BPH in foreign countries is significantly higher than that in China. Generally, the incidence rate is high in the population with a family history of benign prostatic hyperplasia, accounting for more than 1 / 2. [0003] Resear...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/352A61P13/08
Inventor 肖丹边燕红
Owner 成都草木金华科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com