Laryngalgia anti-inflammation traditional Chinese medicinal preparation with improved taste and preparation method thereof

A traditional Chinese medicine preparation and technology for sore throat, applied in the field of sore throat anti-inflammatory traditional Chinese medicine preparations and preparation thereof, can solve the problems such as no disclosure of throat pain anti-inflammatory pills and the like, and achieve the purpose of reducing throat edema and allergy, reducing irritation, and avoiding bitterness and numbness in the tongue. Effect

Inactive Publication Date: 2008-04-30
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In the existing literature, there is no public report on process improvement of Houtong Xiaoyan Pills using cyclodextrin inclusion technology or slow-release material dispersion technology

Method used

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  • Laryngalgia anti-inflammation traditional Chinese medicinal preparation with improved taste and preparation method thereof
  • Laryngalgia anti-inflammation traditional Chinese medicinal preparation with improved taste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Throat pain and anti-inflammatory buccal tablets: A total of 200 buccal tablets are to be prepared. The drug content of each tablet is equivalent to that of the original dosage form of 5 pills, and the rated tablet weight is 0.8g. Take the prescription seven medicinal materials, among which pearl and realgar are separately water-flyed into very fine powder, artificial bezoar, indigo naturalis, and baicao cream are respectively crushed and passed through a No. 9 sieve, and the amount of the above five medicinal materials required to prepare 1000 pills is weighed according to the prescription ratio, Grind, mix, and obtain 2.29 g of medicinal materials; use 8 times the amount of 75% ethanol for toad venom medicinal materials, ultrasonically extract 2 times, extract for 1 hour each time, filter, combine the extracts, evaporate the extracts to dryness in a water bath, and mix with After the above-mentioned filter residues were dried under reduced pressure at 50°C, the dry pro...

Embodiment 2

[0044] Houtong Xiaoyan Dropping Pills: 50g of dropping pills are to be prepared, and the dosage for each dose is 0.5g, which is equivalent to the dosage of the original dosage form of 5 pills. Take the prescription seven medicinal materials, among which pearls and realgar are separately water-flyed into fine powder, artificial bezoar, indigo naturalis, baicao cream, and borneol are crushed respectively and passed through a 200-mesh sieve, and the above 6 kinds required for preparing 500 pills are weighed according to the prescription ratio The amount of medicinal material, research and compound, and mix to get 1.320g medicinal material; according to toad venom: corn protein = 1: 2, weigh the material respectively, stir the corn protein with 10 times the amount of 95% ethanol to make 10% corn protein ethanol solution, toad venom Add the solution, and stir ultrasonically to fully dissolve and disperse toad venom in the corn protein sustained-release liquid; evaporate the ethanol ...

Embodiment 3

[0046] Houtong Xiaoyan Dispersible Tablets: A total of 100 dispersible tablets are planned to be prepared. The drug content of each tablet is equivalent to that of the original dosage form of 5 pills, and the rated tablet weight is 0.8g. Take the prescription seven medicinal materials (same as in Example 1), the pretreatment of the medicinal materials and the inclusion method of toad venom and borneol are the same as in Example 1, mix and prepare each medicinal material and drug inclusion compound according to the equivalent ratio of the prescription medicinal materials; use 15% low-substituted hydroxyl Propyl cellulose (L-HPC), 75% carboxymethyl starch sodium (CMS-Na) as disintegrant, 2% polyvinylpyrrolidone (PVPK-30) in 20% ethanol solution as binder, wet method Granules (20 mesh), dried under reduced pressure at 50°C to obtain granules, added 1.0% magnesium stearate as a lubricant, mixed evenly, and compressed into tablets to obtain Zhonghoutong Xiaoyan Dispersible Tablets o...

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Abstract

The invention relates to a traditional Chinese medicine medicament for laryngalgia and antiphlogosis and process for preparation. The medicament is prepared by applying fluorescence method and dispersion method, wherein the fluorescence method applies beta-cyclodextrin as main additives and toad venom is processed through fluorescence, and then toad venom inclusion complex, other drugs and additives are prepared into medicament preparation. The dispersion method applies zein, acrylic resin and other slow-release materials, and the toad venom which is prepared into dispersion system, other drugs, and additives are prepared into medicament preparation. The medicament for laryngalgia and antiphlogosis of the invention improves the process of the prior Chinese patent medicament laryngalgia antiphlogistic pills and solves the problem of lasting mouth bitter and tongue mottling taste which is caused by toad venom, and thereby patients are pleasant to accept. Positive significance is achieved by taste masking and correcting to toad venom, and meanwhile laryngeal edema and other adverse effects which are caused by strong stimulation and hypersusceptibility of laryngalgia antiphlogistic pills are overcome.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a taste-improving anti-inflammatory traditional Chinese medicine preparation for sore throat and a preparation process thereof. The preparation is prepared by a cyclodextrin inclusion method and a dispersion method. Background technique: [0002] Houtong Xiaoyan Pill is a national standard traditional Chinese medicine preparation, taken orally, with the functions of clearing away heat and detoxification, reducing inflammation and relieving pain, and is used for sore throat caused by excessive heat in the lung and stomach, rotten throat pain, single and double breast moth, larynx aphonia, Water retention, mouth and tongue rot, parotid gland tumors, carbuncle sores, unnamed swollen poison, red tip of the tongue, floating pulse, etc. This variety has a better curative effect, but it has a long-lasting tongue numbness, poor taste, and poor patient compliance. This...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61K36/70A61K9/12A61K9/14A61K9/20A61K9/70A61K47/40A61P11/04A61K31/045A61K33/36A61K35/413A61K35/56
Inventor 任运强丁彦吉樊斌
Owner CHONGQING PHARMA RES INST
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