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Naproxen injection and preparation method thereof

A technology for injection and naproxen, which is applied in the field of naproxen injection and its preparation, can solve the problems of inconvenient use, small quantity and variety, poor stability, etc., and achieves scientific formulation, long half-life and simple production process. Effect

Inactive Publication Date: 2008-05-21
浙江道格凯特实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the number and types of Naproxen injections currently on the market are small, poor in stability, easy to precipitate, and not very convenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of Naproxen injection, made according to the following method:

[0029] (1). Take 2.5 parts of Naproxen and 60 parts of ethanol respectively by weight and mix them;

[0030] (2). Add 20 parts of propylene glycol to the mixture and stir evenly;

[0031] (3). Use hydrochloric acid or sodium hydroxide to adjust the pH value of the mixed solution to 8.0;

[0032] (4). Add water for injection to 100 parts of the mixed solution and mix evenly, then potting and sterilizing to prepare a Naproxen injection.

Embodiment 2

[0034] (1). Take 1 part of Naproxen and 50 parts of ethanol respectively by weight and mix them;

[0035] (2). Add 10 parts of propylene glycol to the mixture and stir evenly;

[0036] (3). Use hydrochloric acid or sodium hydroxide to adjust the pH value of the mixed solution to 7.5;

[0037] (4). Add water for injection to 100 parts of the mixed solution and mix evenly, then potting and sterilizing to prepare a Naproxen injection.

Embodiment 3

[0039] (1). Take 5 parts of Naproxen and 60 parts of ethanol respectively by weight and mix them;

[0040] (2). Add 30 parts of propylene glycol to the mixture and stir evenly;

[0041] (3). Use hydrochloric acid or sodium hydroxide to adjust the pH value of the mixed solution to 9.0;

[0042] (4). Add water for injection to 100 parts of the mixed solution and mix evenly, then potting and sterilizing to prepare a Naproxen injection.

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PUM

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Abstract

The invention relates to a naproxen injection and the preparation method thereof, and the composition and the weight parts of the injection are: 1 to 5 parts of naproxen; 50 to 70 parts of ethanol; 10 to 30 parts of propylene glycol and 5 to 30 parts of injection water. The steps of the preparation method are that: (1) the naproxen and ethanol are respectively weighed and mixed according to the weight parts of the mixing ratio; (2) the propylene glycol is added in the mixed liquid according to the weight parts and is evenly stirred; (3) the pH value of the mixed liquid is regulated to 7.5 to 9.0; (4) the injection water is added in the mixed liquid according to the weight parts and is evenly mixed, and then the naproxen injection finished product is prepared by filling-sealing and sterilization. The invention has scientific formula, simple processing technique and good absorption of intramuscular injection, and more than 99 percent drug of the injection liquid can be combined with blood protein. The half-life is longer, the anti-inflammatory and analgesic effects are better than those of the salicylic acid and acetanilide antipyretic analgesic drugs, and the invention is applicable to a large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of chemical preparations, in particular to a Naproxen injection and a preparation method thereof. Background technique [0002] Naproxen, chemical name: naproxen, Xiaotongling, (+)-a-methyl-6-methoxy-2-naproxen; molecular formula C14H1403; molecular weight 230.26, is a non-steroidal anti-inflammatory Analgesics, used to relieve fever, inflammation and pain associated with arthritis or other symptoms, with anti-inflammatory, antipyretic, and analgesic effects. Naproxen can effectively inhibit the action of prostaglandin synthase, reduce or even stop the release of prostaglandin, so as to play a role. However, the number and types of Naproxen injections currently on the market are small, poor in stability, easy to separate out, and inconvenient to use. Contents of the invention [0003] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a Naproxen injection with good st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K47/10A61P29/00
Inventor 张兴龙华云芳许新增
Owner 浙江道格凯特实业有限公司
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