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Cromoglyn sodium gel eyedrop and preparation method

A technology of sodium cromoglycate and eye drops, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor drug absorption and short residence time, and reduce irritation Sexuality, high surface activity, and strong adhesion

Inactive Publication Date: 2008-05-28
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention discloses a cromoglycate sodium gel eye drop and a preparation method thereof, the purpose of which is to provide a practical, convenient and reliable ophthalmic preparation for treating allergies for the clinic, and to solve the retention time of the eye drop formulation drug in the eye Short, poor drug absorption problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Sodium cromolyn eye drops during the day

[0033] Get 5kg of deionized water, add cromolyn sodium 0.2kg, stir to dissolve. Take 30g Carbomer 934p and 50g HPMC, sprinkle them into the above solution, and let it stand overnight. Then add 3g vitamin B6, 3g ethylparaben, 3g disodium edetate, stir well, store at 4°C for 24 hours, add water to make up 10kg, filter, and sterilize the filtrate by steam at 100°C for 30 minutes; sterile Subpackage.

Embodiment 2

[0035] Get 5kg of deionized water, add cromolyn sodium 0.2kg, stir to dissolve. Take 25g of Carbomer 934p and 50g of HPMC, sprinkle them into the above solution, and let it stand overnight. Then add 3g vitamin B6, 3g ethylparaben, 3g disodium edetate, stir well, store at 4°C for 24 hours, add water to make up 10kg, filter, and sterilize the filtrate by steam at 100°C for 30 minutes; sterile Subpackage.

Embodiment 3

[0037] Get 5kg of deionized water, add cromolyn sodium 0.2kg, stir to dissolve. Take 30g of Carbomer 934p and 45g of HPMC, sprinkle them into the above solution, and let it stand overnight. Then add 3g vitamin B6, 3g ethylparaben, 3g disodium edetate, stir well, store at 4°C for 24 hours, add water to make up 10kg, filter, and sterilize the filtrate by steam at 100°C for 30 minutes; sterile Subpackage.

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PUM

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Abstract

The invention discloses a disodium cromoglycate gel eye drop and the preparation method thereof. The invention uses disodium cromoglycate as main component, supplemented by Vitamin B6 for protecting eye nerves and the excipients include adhesive, surface active agent, gel matrix, isoosmotic adjusting agent, pH moderator, antiseptics, antioxidant and water for injection. The invention is disodium cromoglycate dual purpose gel eye drop for both day and night usages. The invention aims to provide a practical, convenient and reliable ophthalmic preparation for treating allergy, solving the problems of short retaining time and poor drug absorption at eye region of eye drop preparation.

Description

technical field [0001] The invention provides a cromolyn sodium gel eye drop, which contains an active ingredient of cromolyn sodium. The invention also discloses a preparation method thereof, which relates to the technical field of production of ophthalmic pharmaceutical preparations. Background technique [0002] Sodium cromoglycate, an anti-allergic drug, was developed and marketed in 1969. It has a good preventive effect on immediate and delayed allergic reactions, and it is recorded in the pharmacopoeias of the United States, Britain, Japan and China. Indications for acute and chronic allergic keratosis, conjunctivitis and other allergic eye diseases. [0003] At present, its conventional dosage forms are eye ointment and eye drops. Eye drops are low in cost, easy to prepare, convenient to use, non-invasive preparations, and are accepted by a large number of patients. However, eye drops have low bioavailability, need long-term administration, and are likely to cause lo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/00A61K47/32A61K47/34A61K47/36A61K47/38A61P27/02A61K47/10
Inventor 滕利荣程瑛琨孟庆繁张鹏南红梅贾志刚
Owner JILIN UNIV
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