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Therapeutic agent for keratoconjunctival disorder

A cornea and conjunctivitis technology, applied in sensory diseases, aerosol delivery, drug combination, etc., can solve the problem of no research on the pharmacological effects of eye diseases such as corneal and conjunctival lesions, and achieve the effect of improving the effect

Inactive Publication Date: 2008-07-30
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is no report on the pharmacological effects of the above-mentioned compounds on eye diseases such as keratoconjunctivopathy

Method used

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  • Therapeutic agent for keratoconjunctival disorder
  • Therapeutic agent for keratoconjunctival disorder

Examples

Experimental program
Comparison scheme
Effect test

preparation example 2

[0054] 100ml

[0055] Compound B 100mg

[0056] Sodium chloride 800mg

[0057] Disodium hydrogen phosphate 100mg

[0058] Sodium dihydrogen phosphate amount

[0059] Appropriate amount of sterilized distilled water

[0060] By changing the amount of compound B added, the concentration can be adjusted to 0.01% (w / v), 0.3% (w / v), 0.5% (w / v), 1.5% (w / v), 3% (w / v ) eye drops.

preparation example 3

[0062] 100g

[0063] Compound A 0.3g

[0064] Liquid paraffin 10.0g

[0065] Appropriate amount of white petroleum jelly

[0066] Eye ointments with concentrations of 1% (w / w) and 3% (w / w) can be prepared by changing the amount of compound A added.

preparation example 4

[0068] 100g

[0069] Compound B 0.3g

[0070] Liquid paraffin 10.0g

[0071] Appropriate amount of white petroleum jelly

[0072] Eye ointments with concentrations of 1% (w / w) and 3% (w / w) can be prepared by changing the amount of compound B added.

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Abstract

An object of the present invention is to discover a new medicinal use of 5-[4-[[3-methyl-4-oxo-3,4-dihydro-2-quinazolinyl]methoxy]p henylmethyl]thiazolidine-2,4-dione and N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine. Both of the compounds exert an excellent improving effect on corneal disorder models and is useful as a therapeutic agent for a keratoconjunctival disorder such as dry eyes, corneal ulcer, keratitis, conjunctivitis, superficial punctate keratopathy, corneal epithelial defects, conjunctive epithelial defects, keratoconjunctivitis sicca, superior limbic keratoconjunctivitis and filamentary keratitis.

Description

[0001] This application is a divisional application of an application with an application date of October 29, 2004, an application number of 200480031991.4 (international application number of PCT / JP2004 / 016460), and an invention title of "agent for treating keratoconjunctivopathy". technical field [0002] The present invention relates to containing 5-[4-[[3-methyl-4-oxo-3,4-dihydro-2-quinazolinyl]methoxy]phenylmethyl]thiazolidine-2,4 -Diketone, N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy] Phenyl]methyl]glycine or salts of the above compounds as active ingredients dry eye, corneal ulcer, keratitis, conjunctivitis, punctate superficial keratosis, corneal epithelial defect, conjunctival epithelial defect, keratoconjunctivitis sicca, upper A therapeutic agent for keratoconjunctivitis such as superior limbic keratoconjunctivitis and filamentous keratitis. Background technique [0003] The cornea is a transparent, avascular tissue with a diamete...

Claims

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Application Information

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IPC IPC(8): A61K31/517A61K31/421A61K9/06A61K9/08A61P27/02C07D263/32C07D417/12
Inventor 中村雅胤平井慎一郎
Owner SANTEN PHARMA CO LTD
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