Policresulen vaginal gel and preparation thereof

A polycresol and vaginal gel technology, which is applied in the field of medicine, can solve the problems of uneven drug dispersion, narrow spreading area, slow drug effect, etc.

Inactive Publication Date: 2008-08-13
刘全胜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The suppository has a process of softening and dissolving in the vagina, and the drug effect is slow, and the drug is dispersed unevenly and the spreading surface is narrow; in addition, when the suppository is used, the patient has a foreign body sensation in the body, which will bring discomfort to the patient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Polycresol 90g

[0014] Carbopol 940 50g

[0015] PEG4000 200g

[0016] Propylene glycol 300g

[0017] Polysorbate 80 350g

[0018] Ethylparaben 15g

[0019] EDTA-2Na 2g

[0020] Triethanolamine 68g

[0021] Ethanol 1100g

[0022] Distilled water 830g

[0023] Prepare 1000 sticks. Specifications: Each stick contains 90mg of polycresol sulfonal, 3g per stick.

[0024] Preparation method: take Carbopol 940 and pass it through a 100-mesh sieve for later use; take appropriate amount of distilled water, heat it at 50-60°C, and keep warm and stir, first dissolve ethylparaben and EDTA-2Na in water, and then dissolve Carbopol 940 several times Add the above warm water to make it swell into a uniform colloid; dilute triethanolamine with an appropriate amount of distilled water, keep warm and stir, slowly add to the above colloid, stir evenly to obtain component A, and keep warm; take PEG4000, ethanol, propylene glycol 1. Polysorbate 80, heated to 50-60°C, under heat pre...

Embodiment 2

[0026] Polycresol 90g

[0027] Carbopol 940 36g

[0028] PEG4000 210g

[0029] Propylene glycol 270g

[0030] Polysorbate 80 320g

[0031] Ethylparaben 12g

[0032] EDTA-2Na 1.2g

[0033] Triethanolamine 49g

[0034] Ethanol 980g

[0035] Distilled water 1032g

[0036] Prepare 1000 sticks. Specifications: Each stick contains 90mg of polycresol sulfonal, 3g per stick.

[0037] Preparation method: take Carbopol 940 and pass it through a 100-mesh sieve for later use; take appropriate amount of distilled water, heat it at 50-60°C, and keep warm and stir, first dissolve ethylparaben and EDTA-2Na in water, and then dissolve Carbopol 940 several times Add the above warm water to make it swell into a uniform colloid; dilute triethanolamine with an appropriate amount of distilled water, keep warm and stir, slowly add to the above colloid, stir evenly to obtain component A, and keep warm; take PEG4000, ethanol, propylene glycol 1. Polysorbate 80, heated to 50-60°C, under heat p...

Embodiment 3

[0039] Polycresol 90g

[0040] Carbopol 940 56g

[0041] PEG4000 150g

[0042] Propylene glycol 330g

[0043] Polysorbate 80 390g

[0044] Ethylparaben 20g

[0045] EDTA-2Na 2.1g

[0046] Triethanolamine 75g

[0047] Ethanol 1120g

[0048] Distilled water 770g

[0049] 1000 sticks were prepared Specifications: Each stick contains 90mg polycresol sulfonal, 3g / stick

[0050] Preparation method: take Carbopol 940 and pass it through a 100-mesh sieve for later use; take an appropriate amount of distilled water, heat it at 50-60°C, and under heat preservation and stirring, first dissolve ethylparaben and EDTA-2Na in water, and then dissolve Carbopol 940 in batches Add the above warm water to make it swell into a uniform colloid; dilute triethanolamine with an appropriate amount of distilled water, and slowly add it to the above colloid under heat preservation and stirring, and stir evenly to obtain component A, and keep it warm; take PEG4000, ethanol, propylene glycol 1. P...

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PUM

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Abstract

The invention discloses a policresulen sulfonamide-formaldehyde vaginal gel, which is characterized in that the invention comprises the following components: policresulen sulfonamide-formaldehyde, Carbopol, PEG, propanediol, polysorbate, ethyl hydroxy benzoate, EDTA-2Na, trolamine, ethanol and distilled water. The invention has little acrimony, without foreign body sensation for sufferers, and is easily accepted by sufferers with rapid effect.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to a polycresol vaginal gel for treating gynecological diseases. Background technique [0002] Due to many factors such as environmental pollution, competitive pressure, accelerated work pace and changes in lifestyle, the incidence of female gynecological diseases has increased significantly, and it is showing a younger trend. At present, gynecological inflammation has become a common and frequently-occurring disease, seriously perplexing women's health. There are many medicines for the treatment of gynecological inflammation today, but the curative effects are not very satisfactory. Therefore, there is an urgent need for a drug with good curative effect on the market to meet the needs of female patients. Thus, polycresol and its preparations appeared on the market. [0003] Polycresol is a strongly acidic substance. The mechanism of action of polycresol sulfonal is to kill va...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/795A61K47/34A61P15/00A61K47/32
Inventor 刘全胜马明夏兵曹俊
Owner 刘全胜
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