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Self penetration-promoting pressure-sensitive adhesive containing alcoholic acid oligomer and application thereof

An oligomer, pressure-sensitive adhesive technology, applied in the directions of medical preparations containing active ingredients, medical preparations with non-active ingredients, adhesives, etc. Phase system, poor compatibility and other problems, to achieve good percutaneous penetration performance, is conducive to the effect of percutaneous release

Inactive Publication Date: 2008-08-13
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the tightness of the stratum corneum of the skin, it is difficult for many drugs to penetrate the skin to achieve effective therapeutic effects. Only a few types of drugs can be used for transdermal administration, and most of them require the use of penetration enhancers, such as azone, Propylene glycol, menthol, etc. to promote the permeability of the stratum corneum of the skin
The application of these penetration enhancers has a greater impact on the adhesiveness of the adhesive matrix for transdermal administration, that is, the pressure-sensitive adhesive. Especially, the application of hydrophilic pressure-sensitive adhesive matrix has become the development trend of transdermal drug delivery patches. However, many oil-soluble penetration enhancers have poor compatibility with these hydrophilic pressure-sensitive adhesive matrices, and it is difficult to form a homogeneous system

Method used

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  • Self penetration-promoting pressure-sensitive adhesive containing alcoholic acid oligomer and application thereof
  • Self penetration-promoting pressure-sensitive adhesive containing alcoholic acid oligomer and application thereof
  • Self penetration-promoting pressure-sensitive adhesive containing alcoholic acid oligomer and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0022] Examples 1-19 The preparation method of the pressure-sensitive adhesive is to add A, B, C components and an appropriate amount of water into the container according to the metering, stir to mix evenly, and heat appropriately to promote mixing, and then coat after mixing evenly, 60-80 It can be dried at ℃ until the water content is 5-50%. Non-water-soluble samples can be made into a solution with a water-soluble solvent (either ethanol or acetone) and then mixed. The compositions of the pressure-sensitive adhesives in Examples 1-19 are shown in Table 1, and the properties are shown in Table 2.

[0023] Table 1 Composition of hydrophilic blended pressure-sensitive adhesives in Examples 1-22

[0024]

[0025] Note: PVP is poly N-vinylpyrrolidone; PVC is poly N-vinyl caprolactam; PDLLA is poly D, L lactic acid; PCL is polycaprolactone diol; PEG is polyethylene glycol; PHB is polyhydroxybutyric acid; PAA is polyacrylic acid; PEI is polyethyleneimine; PPO is polypropylen...

example 20～23

[0027] Weigh 10 g of the blended pressure-sensitive adhesive in the example (taking the pressure-sensitive adhesive described in Example 12 as an example), add 10 g of a prepared 5% ethanol solution of salicylic acid, mix well, evaporate and remove ethanol, and then Coating on the non-woven fabric made salicylic acid transdermal patches (TDDs1); prepared transdermal patches of ibuprofen, diclofenac and metronidazole in the same way, TDDs2, TDDs3, TDDs4 respectively.

example 24～27

[0029] Weigh 10 g of the blended pressure-sensitive adhesive in the example (taking the pressure-sensitive adhesive described in Example 12 as an example), add 10 g of the prepared 5% ethanol solution of salicylic acid and 0.5 g of azone, mix well, evaporate Remove ethanol, then carry out coating on non-woven fabric and make salicylic acid transdermal patch (TDDs5) containing azone; prepare the transdermal patch of ibuprofen, diclofenac, metronidazole containing azone in the same way Absorption patches, respectively TDDs6, TDDs7, TDDs8.

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Abstract

The invention relates to a hydroxyl acid oligomer-containing self-penetrating pressure sensitive adhesive and application thereof, comprising high hydrophilicity component polymer with relative molecular mass, selected from N-vinyl pyrrolidone with relative molecular mass from 100 thousand to 2000 thousand and its alkyl substituted homopolymer of derivative and copolymer, etc. accounting for 30% to 70%, further comprising lactic acid, oligomers of hydroxyl acids of hydroxyacetic acid accounting for 10% to 40% with polymerization degree from 2 to 8 and short chained polylol with relative molecular mass 300 or below and amine and their mixture and water. The invention has features of hydroscopicity and elasticity of aquagel, further greater pressure sensitive adhesive property which can be applied independently or combined with medicament, surface active agent, electrolyte, penetration enhancer or various inorganic and organic additives for pressure sensitive adhesive, for medicament percutaneous absorption preparation system and treatment of skin diseases, hairdressing, skin protection.

Description

technical field [0001] The invention relates to a self-promoting permeable pressure-sensitive adhesive containing hydroxyacid oligomers and its application, which is a hydrophilic polymer with a relatively high molecular weight, hydroxyacid oligomers, a water-soluble liquid plasticizer and water The formed blend has the characteristics of water absorption and elasticity of the hydrogel, and also has good pressure-sensitive adhesive properties. Background technique [0002] Transdermal drug delivery is a new drug delivery technology that uses the skin as a drug delivery channel, and the drug enters the systemic circulation at a constant rate through the skin. The advantage is that the drug is not affected by the "first-pass effect" of the liver and gastrointestinal tract. , high drug utilization, and can reduce the damage to the stomach and liver at the same time; easy to use, with the ability to release drugs and so on. However, due to the tightness of the stratum corneum o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J7/02A61K47/32A61K47/34A61K45/00A61K8/72A61Q19/00A61P17/00A61L15/22A61L15/58
Inventor 董岸杰李军邓联东
Owner TIANJIN UNIV
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