Pharmaceutical combination for preventing and treating motion sickness and preparations thereof

A composition and technology for motion sickness, applied in the direction of drug combination, drug delivery, active ingredients of heterocyclic compounds, etc., can solve problems such as drug withdrawal rebound, travel, inconvenient life, blurred vision, etc.

Active Publication Date: 2008-08-20
SUN YAT SEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main anti-motion sickness drugs on the market have many side effects, especially side effects such as drowsiness, fatigue, blurred vision and memory impairment, and there is also a phenomenon of rebound after stopping the drug, which brings a lot of inconvenience to travel and life

Method used

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  • Pharmaceutical combination for preventing and treating motion sickness and preparations thereof
  • Pharmaceutical combination for preventing and treating motion sickness and preparations thereof
  • Pharmaceutical combination for preventing and treating motion sickness and preparations thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Get caffeine 200g, chlorpheniramine maleate 8g. First mix 8 g of chlorpheniramine maleate and 30 g of starch, then mix with caffeine, then add 2 g of micropowdered silica gel, mix evenly, pack into 1000 capsules, and obtain capsules.

Embodiment 2

[0010] Take 200g of caffeine, 8g of chlorpheniramine maleate, add 30g of starch and mix evenly, then add 2g of micropowdered silica gel, mix evenly, and pack into 1000 capsules to obtain capsules.

Embodiment 3

[0012] Get caffeine 200g, chlorpheniramine maleate 8g. First mix 8 g of chlorpheniramine maleate and 130 g of starch, then mix with caffeine, wet granulate, dry the granules, add 2 g of micropowdered silica gel, mix evenly, and press into 1000 tablets to obtain tablets.

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Abstract

The invention relates to a drug composition for the treatment of motion sickness, as well as the preparation, wherein the drug composition comprises caffeine and chlorpheniramine maleate; 50 to 500 mg caffeine and 2 to 20 mg chlorpheniramine maleate are contained in each preparation unit; the preferred mass ratio of caffeine to chlorpheniramine maleate in each composition is 50:2 and the preferred amount of each component is 200 mg caffeine and 8mg chlorpheniramine maleate. The drug composition has an advantage of effectively treating and preventing motion sickness without side effect of sleepiness or lassitude; besides, conventional adjuvant can be added in the drug composition to make drugs through any conventional method for motion sickness treatment; controlled release technologies can also be adopted to make controlled release preparations.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating motion sickness and its preparation. Background technique [0002] Motion sickness is a common disease. It is a disorder of the autonomic nervous system caused by excessive bioelectricity caused by the stimulation of the vestibular balance receptors in the inner ear. , When the ship shakes and bumps, when the elevator and the plane go up and down. Everyone has a limit to the intensity and time tolerance of exercise stimulation, and this limit is the dizziness threshold. Within a certain limit and time, people will not have adverse reactions. If the stimulus exceeds this limit, symptoms of motion sickness will appear. Usually, fatigue or dizziness will appear first, followed by yawning, salivation and increased swallowing movements, chest tightness, breathlessness, etc. Symptoms such as headache, followed by nausea and vomiting; some patients have abdominal pain, blurred...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K9/20A61K9/22A61K9/48A61K9/52A61K47/36A61K47/40A61P1/08A61K31/4402
Inventor 苏薇薇杨斌向飞军徐铁峰李沛波王永刚郭静彭维项辉朱颖虹
Owner SUN YAT SEN UNIV
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