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Method for improving supercritical CO2 abstraction propolis obtaining ratio

A supercritical, glue-yielding technology, applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, unknown raw materials, etc., can solve the problems that hinder the improvement of fluid extraction propolis, propolis hardening, high production costs, etc., to improve the extraction of propolis The effect of high efficiency, uniform distribution of propolis and low production cost

Inactive Publication Date: 2011-07-20
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, supercritical CO 2 The extraction rate of fluid extraction propolis still stays at 6%-10% (including the use of carrier), the extraction efficiency is low, the extracted propolis residue is easy to agglomerate, and the production cost is high
Supercritical CO 2 The problem of low extraction rate of propolis has not been effectively broken through, which restricts the application of this technology in propolis processing
[0004] After research, it was found that it hinders the improvement of supercritical-CO 2 The key problem of the extraction rate of propolis in fluid extraction is that propolis is easy to harden, even if it is crushed granular propolis after freezing, the propolis in supercritical CO 2 During the fluid extraction process, due to the influence of heat, pressure and other factors, propolis also hardens in the kettle
During the extraction process, propolis appeared large-area or local hardening phenomenon, CO 2 The fluid cannot contact the propolis evenly and smoothly
CO 2 When the fluid passes through the extraction tank, its flow resistance varies, CO 2 Fluid flows through places with low resistance, resulting in channeling phenomenon, CO 2 The fluid is short-circuited, and propolis cannot interact with CO 2 Sufficient fluid contact, resulting in low extraction rate of propolis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Rinse the fine river sand below 10 mesh and dry it for later use. The raw material propolis (block glue, sand glue, cloth glue can be used) is cryogenically frozen and pulverized into granules. Mixing ratio and method of river sand and propolis: 1 kg of granular propolis and 5.3 kg of river sand can be mixed with a drum mixer for 15 minutes, or manually mixed, and the river sand and propolis can be mixed evenly without obvious phenomenon of separation.

[0011] Put the mixed river sand and propolis into the material bucket, do not compact it artificially, the evenly distributed river sand forms a stable network skeleton support system. Place the loaded barrel in the extraction kettle, close the sealing gland of the extraction kettle, and start the supercritical-CO 2 Fluid extraction device. Extraction condition control: extraction kettle temperature 55°C ±2 , separator temperature 55°C ±2 , extraction pressure 30MPa, CO 2 The flow rate is 150L / h-250L / h, and the ex...

Embodiment 2

[0014] Rinse the river sand below 10 mesh and dry it for later use. Take the propolis slag after ethanol extraction, cryogenically freeze and pulverize into granules. Mixing ratio and method of river sand and propolis: 1L (cumulative volume) of granular propolis slag is mixed with 1.2-1.5L (cumulative volume) of river sand. Since the bucket is measured by volume, sometimes it is more convenient to use the volume ratio. Use a drum mixer to mix for 15 minutes, or manually mix, mix the river sand and propolis evenly, and there should be no obvious separation.

[0015] Put the mixed river sand and propolis into the bucket, do not compact it artificially. Place the loaded barrel in the extraction kettle, close the sealing gland of the extraction kettle, and start the supercritical-CO 2 Fluid extraction device. Extraction condition control: extraction kettle temperature 55°C ±2 , separator temperature 55°C ±2 , extraction pressure 30MPa, CO 2 The flow rate is 150L / h-250L / h, an...

Embodiment 3

[0018] Rinse the river sand below 10 mesh and dry it for later use. Get raw propolis (block glue, sand glue, cloth glue all can) and remove beeswax (raw material propolis generally contains beeswax content all reaches 30%-40%, what have is up to 50%). Dewaxing method: heat the raw propolis to 75°C-78°C, the beeswax will overflow by itself, this method can remove 80%-90% of the beeswax in the propolis. The dewaxed propolis is then cryogenically frozen and pulverized into granules for later use. Mixing ratio and method of river sand and propolis: 1 kg of granular propolis and 5.3 kg of river sand can be mixed with a drum mixer for 15 minutes, or manually mixed, and the river sand and propolis can be mixed evenly without obvious phenomenon of separation.

[0019] Put the mixed river sand and propolis into the material barrel, do not compact it artificially, put the material barrel in the extraction kettle, close the sealing gland of the extraction kettle, and start the supercri...

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Abstract

The invention relates to a yield increasing method for propolis with supercritical CO2 extraction, which comprises the following steps: fine riversand and propolis are mixed evenly in certain proportion and then are put in extraction kettle; the supercritical CO2 fluid extraction device is started according to the operational instruction; the mixture is extracted based on the set temperature, pressure, time and CO2 flow to obtain aromatic propolis in light yellow color. The method is not only suitable for blocky proposes, sand proposes and dispending proposes, but also suitable for the propolis residues after ethanol extraction method. The method has the advantages that: firstly, the material of riversand is available easily, low in cost and has no pollution; secondly, the propolis has uniform distribution, stable structure and does not collapse due to the reticular framework support structure; thirdly, the yield of propolis is hight; fourthly, the technology is simple and the production cost is low.

Description

technical field [0001] The invention relates to a method of improving supercritical-CO 2 A method for extracting propolis yield. Background technique [0002] The word propolis comes from Greece. It is a resinous substance secreted by bees from young shoots and calluses of poplar, pine, and other plants mixed with the secretions of their own digestive glands and wax glands. Formed a complex chemical composition, with a viscous natural mixture, has a variety of biological activities and important health functions. [0003] At present, the extraction of propolis in China mainly uses organic solvent extraction, and the product contains solvent residues and high lead content, which requires further processing to remove lead before eating. supercritical-CO 2 The propolis product of fluid extraction has the advantages of strong propolis aroma, light yellow color, bright color, no organic solvent residue, and low lead content (about 5 times lower than the national standard). Ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A23L1/076A23L21/20A61K35/644
Inventor 张彬周武
Owner NANCHANG UNIV
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