Technology for producing radix astragali polysaccharide by utilization of alkaline process extraction technology

An astragalus polysaccharide and alkaline extraction technology, applied in the directions of antibacterial drugs, antiviral agents, drug combinations, etc., can solve the problems of the purity and low extraction rate of astragalus polysaccharides, achieve ecological feeding, improve immunity, and improve economic value Effect

Inactive Publication Date: 2016-03-16
陈燕妮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of the existing medicinal licorice extracts of astragalus polysaccharides such as low purity and low extraction rate, and to provide a process for producing astragalus polysaccharides using water extraction technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] In this embodiment, dry Radix Astragali is used as a raw material, and the preparation method steps include:

[0020] 1) Acquisition of crude extract: 1 kg of dried Astragalus root raw material, washed, dried and crushed, then added with 5 times of water (cleaned with clean water for 3 times, crushed into astragalus root to 50 mesh), added with 2 times of alkaline solution, 50°C After soaking at a constant temperature for 2 hours under certain conditions, the alkaline hydrolysis solution was filtered out, and the extraction was repeated 3 times, and the combined extracts were left to cool to obtain a crude extract; The contents of sodium carbonate, sodium bisulfite and calcium chloride in the leaching solution are 30%, 15% and 40% respectively.

[0021] 2) Concentration and evaporation: Add the natural plant extract clarifier KBT-ZTC produced by Kelier Biotechnology Co., Ltd. to the crude extract obtained in step 1, the addition amount is 5g / L, and after standing for 30...

Embodiment 2

[0025] 1) Acquisition of crude extract: 1 kg of dried Astragalus root raw material, washed, dried, and crushed, then added with 10 times of water (cleaned with clean water twice, crushed into astragalus root to 100 mesh), added with 3 times of alkaline solution, 40°C After soaking at a constant temperature for 3 hours under the condition, the alkaline hydrolysis solution was filtered out, and the extraction was repeated 3 times, and the combined extracts were left to cool to obtain a crude extract; The contents of sodium carbonate, sodium bisulfite and calcium chloride in the leaching solution are 15%, 30% and 10% respectively.

[0026] 2) Concentration and evaporation: Add the natural plant extract clarifier KBT-ZTC produced by Kelier Biotechnology Co., Ltd. to the crude extract obtained in step 1, and the addition amount is 10g / L. After standing for 20 minutes, rotate and evaporate to concentrate Crude extract, to the extract whose water specific gravity d is 1.0, obtains th...

Embodiment 3

[0030] 1) Acquisition of crude extract: 1 kg of dried Astragalus root raw material, washed, dried and crushed, then added with 8 times of water (cleaned with clean water for 3 times, crushed into astragalus root to 75 mesh), added with 3 times of alkaline solution, 45°C After soaking at a constant temperature for 3 hours under the condition, the alkaline hydrolysis solution was filtered out, and the extraction was repeated 3 times, and the combined extracts were left to cool to obtain a crude extract; The contents of sodium carbonate, sodium bisulfite, and calcium chloride in the leaching solution are 20%, 20%, and 30%, respectively.

[0031] 2) Concentration and evaporation: Add the natural plant extract clarifier KBT-ZTC produced by Kelier Biotechnology Co., Ltd. to the crude extract obtained in step 1, the addition amount is 7.5g / L, let stand for 25min and then rotate to evaporate Concentrating the crude extract to obtain an extract whose water specific gravity d is 1.20 to...

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Abstract

The invention relates to the radix astragali medicine extraction technology field, and concretely provides a technology for producing radix astragali polysaccharide by utilization of an alkaline process extraction technology. The method comprises steps: dried radix astragali roots are taken, cleaned, dried, crushed, added with an alkaline hydrolysis liquid, and soaked for 2-3h at a constant temperature, extraction is repeated for three times, the extracting solutions are merged and the mixture is allowed to stand for cooling, a natural plant extracting solution clarificant KBT-ZTC is added, the crude extracting solution is condensed through rotary evaporation after standing and an extract crude product is obtained; ethanol is added in the extract crude product, the extract is stirred and dissolved, the mixture is allowed to stand for precipitation, centrifugation is carried out, the supernatant is removed and sediments are obtained; ethanol is added again, stirring and centrifugation are carried out and a pure product radix astragali polysaccharide is prepared. Based on a normal water extraction alcohol precipitation method, the plant traditional Chinese medicine clarification technology is introduced to achieve extraction and purification of high-quality radix astragali polysaccharide. The extraction yield of active ingredients in radix astragali polysaccharide is raised, and the radix astragali polysaccharide extraction rate of the improved method is more than 10.6%, the highest being 13.5%.

Description

technical field [0001] The invention belongs to the technical field of astragalus medicine extraction, and in particular relates to a process for producing astragalus polysaccharides by using an alkali extraction technique. Background technique [0002] Astragalus is a leguminous plant, sweet in taste, slightly warm in nature, and belongs to the lung and spleen meridian. Astragalus polysaccharide (APS) is a polysaccharide extracted from the traditional Chinese medicine Astragalus, mainly composed of fructose, rhamnose, arabinose, hexuronic acid, glucose, galacturonic acid and glucuronic acid. Because it has the functions of enhancing immune system function, anti-tumor, protecting liver, lowering blood sugar, anti-virus, anti-oxidation and delaying aging. In veterinary clinics, astragalus polysaccharides have obvious effects on immune regulation, anti-virus, and anti-bacteria. They are widely used as immune enhancers and immune adjuvants, and can be used to prevent piglet di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61P37/04A61P31/04A61P31/12
CPCC08B37/0003C08B37/00
Inventor 陈燕妮
Owner 陈燕妮
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