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Method of evaluating skin conditions and method of estimating skin thickness

A technology for skin and skin damage, applied in medical science, sensors, diagnostic recording/measurement, etc., which can solve the problems of undisclosed measurement of UV light skin damage and physiological aging

Inactive Publication Date: 2008-09-03
POLA CHEM INDS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of these disclose methods for measuring UV light-induced skin damage and physiological aging, and methods for objectively and quantitatively estimating the respective thicknesses of the epidermis and dermis

Method used

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  • Method of evaluating skin conditions and method of estimating skin thickness
  • Method of evaluating skin conditions and method of estimating skin thickness
  • Method of evaluating skin conditions and method of estimating skin thickness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0164] In the near-infrared absorption spectrum of a collection of skin samples obtained from hairless mouse skin, for 5990-5490cm -1 and 5000-4480cm -1 Data processing in the wavenumber region. Specifically, mean center and standard normal variance (SNV) are performed, followed by second derivatives.

[0165] Divide the data-processed spectra every 4cm -1 Separated, the spectral value (second differential value of absorbance) of each divided spectrum is calculated. A matrix is ​​formed from the calculated second-order differential value of the spectral value for each wave number and skin treatment contents (presence / absence of UV irradiation, difference in irradiation amount, and difference in age). Perform principal component analysis on the resulting matrix. From the obtained analysis results, a plane scatter diagram is formed, assuming that the second principal component is used as the first axis and the third principal component is used as the second axis (the two com...

Embodiment 2

[0168] In Example 1, the near-infrared absorption spectrum of a hairless mouse skin sample whose skin damage degree caused by UV light and skin physiological aging degree are unknown is increased, and the data processing is performed according to the same process as in Example 1 to form a matrix, whereby Perform principal component analysis. Fig. 6 is a scatter diagram formed from the obtained results. As shown in Figure 6, the individual sample groups with different treatment content are clearly categorized, and the graph position of the results for skin samples whose degree of damage and physiological aging caused by UV light is unknown determines that this skin is most equivalent to UV Unirradiated 27-week-old group.

Embodiment 3

[0170] The above-mentioned human skin sample collection was measured and analyzed in the same manner as in Example 1. The analysis results obtained by the multivariate analysis form a flat scatter plot assuming the first principal component as the first axis and the second principal component as the second axis. The resulting flat scatter plots are shown in Figures 7 and 8. The 95% density ellipses classified by site are obtained in FIG. 7 , and the 95% density ellipses classified by age are obtained in FIG. 8 . As shown in Figure 7 or 8, realize that the results are very clearly categorized according to arm position or age. Specifically, the degree of physiological aging is higher toward the left of the first principal component axis (horizontal axis), and the degree of damage caused by UV light is higher toward the lower side of the second principal component axis (vertical axis). Therefore, it is recognized from FIG. 7 that the degree of damage caused by UV light is high ...

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Abstract

The aim of the invention is to evaluate at least one of the degree of skin injury caused by ultraviolet light and the degree of physiological aging of the skin and estimate at least one of the epidermal thickness and dermal thickness of the skin, the near infra-red absorption spectrum of the skin is used and the obtained data are employed in monitoring the skin conditions, evaluating a cosmetic and so on.

Description

technical field [0001] The present invention relates to a method of determining at least one of the degree of skin damage caused by UV light and the degree of physiological aging of the skin, a method of estimating at least one of the thickness of the skin epidermis and the thickness of the dermis, and a method of monitoring the state of the skin by using the results obtained in the above methods and methods of evaluating cosmetics, etc. Background technique [0002] Not only women everyone wants to have beautiful skin. Therefore, in the present situation, most of the women try to keep their skin in good condition by using cosmetics etc. Skin conditions vary greatly from individual to individual. Skin aging is broadly classified into physiological aging (primary physiological aging) that occurs in each individual with aging, and pathological aging caused by UV light (damage caused by UV light or photoaging) (for example, see Non-Patent Document 1). [0003] Changes over t...

Claims

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Application Information

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IPC IPC(8): A61B5/107A61B5/00
Inventor 宫前裕太山川弓香土屋顺子川畑真理绘
Owner POLA CHEM INDS
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