Avermectin and erythromycin synthesis gene cluster fused combination biological synthesis application
A technology of abamectin and biosynthesis, applied in the application, genetic engineering, plant genetic improvement and other directions, can solve the problem of abamectin having no antibacterial activity and the like
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[0042] Embodiment with reference to accompanying drawing
[0043] Figure 1 is a schematic diagram of the procedure for producing novel antibiotic structural analogs according to the present invention.
[0044] A and B: respectively, two gene fragments upstream of the abamectin synthesis gene cluster. The inactivation of this gene will not affect the main functions such as the growth and development of the strain and the production of antibiotics. For the insertion of the kana resistance gene in the genome.
[0045] C: a segment of gene downstream of the abamectin synthesis gene cluster. Used for homologous exchange between genomes during cell fusion.
[0046] D, E: two gene fragments downstream of the erythromycin synthesis gene cluster, respectively. The inactivation of this gene will not affect the main functions such as the growth and development of the strain and the production of antibiotics. Used for the insertion of the ampicillin resistance gene as well as the "C"...
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