Stable lornoxicam solution agent, preparation method and application thereof

A technology of lornoxicam and solution, which is applied in the field of meglumine and phosphate solution and salt, and can solve problems such as turbidity and unstable physical and chemical properties
CN101278906AInactive Publication Date: 2008-10-08南京易亨制药有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
南京易亨制药有限公司
Publication Date
2008-10-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to stable lornoxicam solution and a preparation method and an application thereof; the solution contains the lornoxicam or the pharmaceutically-acceptable salt of the lornoxicam, meglumine, potassium phosphate salt and / or sodium phosphate salt, and has the advantages of good solubility, good stability and good security. The solution of the invention is suitable for parenteral administration such as intramuscular injection, intravenous injection or ophthalmic purpose; the solution which is suitable for the invention is selected from injection preparation, lyophilization formulation or spraying desiccant, preferably the lyophilization formulation.
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Description

technical field

[0001] The invention relates to a stable lornoxicam solution, its preparation method and application, in particular to a solution containing lornoxicam or its pharmaceutically acceptable salt, meglumine and phosphate. Background technique

[0002] In recent years, extensive research has been conducted on non-steroidal anti-inflammatory drugs at home and abroad, and a series of new drugs with clinical treatment prospects have been developed. Among them, Oxycam non-steroidal anti-inflammatory drugs are playing an increasingly important role in clinical practice, especially after the withdrawal of COX-2 inhibitor Vioxx due to adverse reactions, it has inspired many domestic manufacturers to take Oxicam Enthusiasm for R&D and sales of non-steroidal anti-inflammatory drugs.

[0003] Lornoxicam (also known as "fenoxicam") is a new type of non-steroidal analgesic anti-inflammatory drug of the Xicam class, and its chemical name is 6-chloro-4-hydroxy-2-methyl-3-( 2-...

Claims

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