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Intravascular stent with PLGA blend medicament eluting surface coating

A PLGA and surface coating technology, which is applied in the field of medical materials and medical vascular stents, can solve the problems of restricting polymer applications, poor mechanical properties, and loss of function of drug-eluting stents.

Inactive Publication Date: 2008-10-08
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The poor mechanical properties of polylactide PLA itself are mainly reflected in the low plasticity, which can easily cause cracking of the drug-eluting coating during the pre-installation and interventional distraction of the stent, resulting in the loss of the drug-eluting stent function. , which greatly limits the application of this polymer in the preparation of continuous drug-eluting coatings

Method used

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  • Intravascular stent with PLGA blend medicament eluting surface coating
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  • Intravascular stent with PLGA blend medicament eluting surface coating

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specific Embodiment approach 1

[0028] Embodiment 1: First, the two blending components are dissolved in an organic solvent according to the ratio of PEG or PEO:PLGA=1 to 40%, and a uniform polymer solution is prepared. Add the drug to the polymer solution according to the ratio of drug: polymer drug-loaded material = 5% to 40%, and add a certain volume of organic solvent to prepare a uniform coating solution with a certain concentration. Finally, a single-layer drug coating is prepared by ultrasonic atomization and spraying. The specific coating structure is as follows: Figure 1-a , where 1 is the PLGA blend and 2 is the drug.

specific Embodiment approach 2

[0029] Embodiment 2: Prepare the blend drug solution and polymer solution according to the ratio described in the method 1. Spray the blended drug solution and the polymer solution on the surface of the stent by ultrasonic atomization spraying in turn to form a double-layer drug coating. The specific coating structure is as follows: Figure 1-b As shown, 1 is the polymer drug-loaded material, 2 is the drug, and 3 is the non-drug polymer coating.

specific Embodiment approach 3

[0030] Embodiment 3: Prepare several blend drug solutions loaded with the same (or different) drugs and different drug concentrations according to the ratio described in method 1. According to the order of drug concentration from high to low, the blend drug solution is sprayed on the surface of the vascular stent by ultrasonic atomization spraying method to form a multi-layer drug coating. The specific coating structure is as follows: Figure 1-c shown.

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Abstract

The invention provides an intravascular stent coated with a PLGA polymer blend drug-eluting coating on the surface. The stent comprises a bare-metal stent, and on the surface of the bare-metal stent, the PLGA polymer blend drug-eluting coating is applied; the polymer blend of the PLGA polymer blend drug-eluting coating is obtained through the physical blend of L-typed or DL-typed PLGA with a molecular weight of 10,000 to 20,000 and PEG or PEO with a molecular weight of 4,000 to 800,000 and the component proportion of PEG or PEO to PLGA is 1 to 40 percent. The intravascular stent coated with the PLGA polymer blend drug-eluting coating on the surface prepared by the invention can realize the gradual and slow release of drugs and guarantee the good combination performance of the drug coating and the metal stent.

Description

(1) Technical field [0001] The invention relates to a medical material, in particular to a medical vascular stent, which belongs to the technical field of medical instruments. (2) Background technology [0002] In 1977, Gruntzig performed the world's first percutaneous transluminal coronary angioplasty (PTCA), creating a new era of interventional cardiology. In the following 20 years, PTCA-based percutaneous coronary intervention (PCI) technology has developed rapidly and has become an important means of coronary artery revascularization, and its efficacy has been confirmed by large-scale clinical trials of evidence-based medicine. The main problem faced in the development of PCI is restenosis. The incidence of restenosis after PTCA is as high as 30% to 50%. Studies have shown that the mechanisms of restenosis are: ①elastic recoil of blood vessels; ②negative remodeling of blood vessels; ③thrombus formation and organization; Extracellular matrix aggregates. Intravascular u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/10A61L31/16A61F2/82
Inventor 李莉孙宏涛王勇郑玉峰
Owner HARBIN ENG UNIV
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