Pharmaceutical composition

Abstract

The invention discloses a drug composite that is characterized in that after dose-effect relationship experiments, pharmacodynamics verification experiments, pharmacokinetics experiments and toxicology experiments, the drug composite is determined by weight proportion: A1-10 weight portions of salvianolic acid of salvia miltiorrhiza, containing 1-20 weight portions of one or more of general formula drugs; A1-5 weight portions of preferred salvianolic acid of the salvia miltiorrhiza, containing 10-20 weight portions of one or more of general formula drugs; A6-10 weight portions of preferred salvianolic acid of the salvia miltiorrhiza, containing 1-9 weight portions of one or more of general formula drugs. The Pharmacological experiments are proved that the drug composite has very good pharmacological effects.

Description

pharmaceutical composition technical field The present invention relates to the technical field of medicine, in particular to a pharmaceutical composition comprising salvianolic acid A and one or more drugs with the following general formula: formula one formula two formula three Wherein R1, R2, R3, R4 can be H, Na, Mg, K, ammonium; The drug of the above general formula is one or more of glycyrrhizic acid, glycyrrhetinic acid and its derivatives; The medicine with the general formula of the present application can also be licorice fluid extract or licorice extract or licorice fluid extract or licorice extract on page 273 and 274 of "Pharmacopia of the People's Republic of China" (2005 edition, one part). Background technique In modern society, people’s fast pace of life, high work pressure and serious environmental pollution have caused people’s liver overload and decreased immunity. However, the defects of Chinese food culture have further damaged the live...

AI Technical Summary

Problems solved by technology

The traditional Chinese medicine combines salvia miltiorrhiza with licorice to treat liver disease and has achieved certain effects. Chinese patent "200510115662.4" "A Chinese medicine composition and preparation method for liver fibrosis and portal hypertension" combines salvia salvia phenolic acids in salvia miltiorrhiza with licorice Compatibility of extracts to prepare medicines for treating liver diseases; although the above-mentioned medicines have certain medicinal effects, they are only compatible with traditional Chinese medicines or their effective parts to achieve "effective" effects, and there is no research on the active ingredients in traditional Chinese medicines , can not achieve the purpose of "superior effect"; salvianolic acid A [salvianolic acid A] is the most active ingredient in Danshen, and has good pharmacological effects (Du Guanhua [Basic Medicine and Clinical, 2000, 20(5): 10-14 ], Hu Yiyang [Acta Pharmacological Journal of Traditional Chinese Medicine, 1997, 18(5): 478-480]); glycyrrhizic acid, glycyrrhetinic acid and their derivatives in licorice have good pharmacological effects ["Glycyrrhizin active ingredients glycyrrhizic acid and glycyrrhetinic acid Progress in pharmacological action of its derivatives" (Li Cuiqin), "Chinese Medical Research and Practice", Volume 2, No. 3, March 2004, 48-51]; The combination of its derivatives should be a good choice for the treatment of liver diseases; however, the content of salvianolic acid A in Salvia miltiorrhiza is very low, only about 5 / 10,000. Even if it is extracted through a series of processes, only trace amounts can be obtained. Grade salvianolic acid A. Therefore, the traditional Chinese medicine combines salvia miltiorrhiza or salvianolic acid with other medicinal materials. The essence is the compatibility with other relatively weak components of salvia miltiorrhiza (such as tanshinone, salvianolic acid B, etc.). Batch grade Whether there is an intrinsic relationship between the compatibility of salvianolic acid A and the active ingredients of licorice is one of the difficult problems to be solved.

Check the literature and patents, there is no report on the compatibility of salvianolic acid A with glycyrrhizic acid, glycyrrhetinic acid and their medicinal salts, but there is compatibility of salvianolic acid with glycyrrhizic acid, glycyrrhetinic acid and their derivatives. Although the drug combination has a certain curative effect, there are certain defects in the prior art: the obtained salvianolic acid is a salvianolic acid substance based on salvianolic acid B, and it is impossible to obtain batch-level salvianolic acid Therefore, whether batch-level salvianolic acid A can be combined with glycyrrhizic acid and glycyrrhetinic acid and its derivatives requires researchers to determine through a large number of scientific research experiments

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