Waterless Peramivir crystal and medicament composition thereof

Abstract

The invention relates to an anhydrous peramivir crystal compound and a preparation method thereof, and further discloses a pharmaceutical composition comprising the same and the application thereof in the preparation of medicaments for treating the influenza virus and the Avian influenza virus.

Description

Anhydrous peramivir crystal and pharmaceutical composition thereof technical field The invention belongs to the technical field of organic medicinal chemistry, and relates to a crystal form of influenza neuraminidase inhibitor anhydrous Peramivir (Peramivir), a method for preparing the crystal, and a pharmaceutical composition containing the crystal. Background technique Influenza viruses can be divided into three serotypes according to the antigenic properties of their nucleoproteins and matrix proteins, namely influenza A, B, and C, among which influenza A viruses can infect a variety of animals, including humans, poultry, pigs, Ma et al, while B and C influenza viruses are generally more common in human infection. Avian influenza virus is one of type A (ie type A) influenza viruses. In theory, drugs used to treat and prevent influenza A in humans should be effective against bird flu. For example, the current amantadine (amantadine), rimantadine (rimantadine), zanamiv...

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The Chinese patent applications for peramivir include: the patent application with the application number 98812351.7 discloses the peramivir compound, the preparation method and its use, and the patent applications with the application numbers 00809622.8 and 00809654.6 disclose the preparation of peramivir Method and A, B crystal structures containing water of crystallization, but there is no report about anhydrous peramivir crystals

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