Applications of Chinese medicinal composition in preparing medicament for improving function of vascular endothelium

A technology of vascular endothelium and composition, which is applied in the application field of traditional Chinese medicine composition in the preparation of medicines for improving vascular endothelial function, can solve problems such as vascular wall remodeling, vascular structure change, etc., achieve symptom and degree improvement, and improve vascular endothelium effect of function

Inactive Publication Date: 2008-12-17
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The function of vascular endothelium affects the cell repair of blood vessels for a long time. In the case of normal vascular endothelial function, the growth inhibitory effect is greater than the growth promotion. change

Method used

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  • Applications of Chinese medicinal composition in preparing medicament for improving function of vascular endothelium
  • Applications of Chinese medicinal composition in preparing medicament for improving function of vascular endothelium
  • Applications of Chinese medicinal composition in preparing medicament for improving function of vascular endothelium

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Experimental program
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Effect test

Embodiment 1

[0043] Embodiment 1: the preparation of pharmaceutical capsule of the present invention

[0044] prescription:

[0045] Astragalus 450g Aconite 112.5g Ginseng 225g Salvia miltiorrhiza 225g Tinglizi 150g

[0046] Xiangjiapi 180g Alisma 225g Safflower 90g Polygonatum 75g Chenpi 75g Guizhi 90g

[0047] Preparation:

[0048] (1) Radix Astragali, Tinglizi, Alisma, Ginseng, Cyperus bark were extracted twice according to the above prescription plus 8 times the amount of 70% ethanol under reflux, the first time was 3 hours, the second time was 2 hours, the extracts were combined, filtered After passing through, the filtrate is decompressed to recover ethanol, and is concentrated to a clear paste with a relative density of 1.25-1.30 (60°C thermal measurement), for subsequent use;

[0049] (2) Guizhi and tangerine peel are distilled to extract volatile oil according to the proportion, the aqueous solution after oil extraction is filtered, and set aside, and the residue is decocted wi...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparation of a medicine for improving the endothelium function of blood vessels. The traditional Chinese medicine composition of the invention can effectively decrease plasma endothelin (ET) of patients with heart failure, improve the level of nitric oxide (NO) and calcitonin gene-related peptide (CGRP); the traditional Chinese medicine composition of the invention can effectively improve the endothlelium function of blood vessels of patients with chronic heart failure, and the symptoms of heart failure and degree thereof are also reduced with the improvement of the endothelium function of blood vessels.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition in preparing medicines for improving vascular endothelial function. Background technique [0002] Heart failure is the inevitable final outcome of most heart disease patients, and the mechanism is complex. Studies in recent years have shown that vascular endothelial dysfunction plays a very important role in the pathogenesis of heart failure, and may be one of the important factors for the deterioration of patients with heart failure [Huang Shufen. Effects of isosorbide mononitrate on vascular The influence of endothelial function [J] Jilin Medicine, 2007, (02).]. [0003] Patients with heart failure have vascular endothelial insufficiency, the imbalance of nitric oxide (NO) and endothelin (ET) released by endothelial cells, resulting in abnormal endothelium-dependent vasomotion, increa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P9/04
Inventor 吴以岭
Owner HEBEI YILING MEDICINE INST
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