Improved simulated moving bed separation method

A technology of simulating moving bed and separation method, applied in the direction of moving adsorbent separation, ion exchange, ion exchange regeneration, etc., can solve the problems of increasing the amount of eluent, reducing the injection volume Feed, and increasing the system pressure. The effect of high injection fluid flow and reduced dosage

Inactive Publication Date: 2008-12-24
NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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Problems solved by technology

[0011] From formula (4~5), when the difference between the adsorption equilibrium constants of the two separated components (K 2 -K 1 ) increases, it is beneficial to improve the injection volume Feed, but this time will increase the amount of eluent Eluent, and thus bring the negative impact of system pressure rise; on the contrary, when the difference between the adsorption equilibrium constants of the two components (K 2 -K 1 ) is reduced, although the amount of eluent used in Zone I can be reduced, but at this time the injection volume Feed will be reduced

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Examples

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Embodiment 1

[0050] Example 1 Conventional Simulated Moving Bed Separation

[0051] Use methanol / water (volume ratio is 65 / 35) solution preparation concentration to be the capsaicin total alkaloid solution of 40mg / mL, it is pumped into separation system with 1.4mL / min flow rate from the sample liquid inlet between II area and III area , and the methanol / water (volume ratio 60 / 40) solution is used as the eluent, and flows into the I zone together with the IV zone effluent from the eluent inlet between the I zone and the IV zone at a flow rate of 2 mL / min. The flow rates in zones I to IV were set at 12, 4.5, 5.9, and 4 mL / min, respectively. Switching time is set to 10min.

[0052] The extract and raffinate were detected by high performance liquid chromatography, and the results showed that the strongly adsorbed components and weakly adsorbed components had been completely separated.

Embodiment 2

[0053] Example 2 Conventional Simulated Moving Bed Separation

[0054] With methanol / water (volume ratio 95 / 5) solution preparation concentration is the capsaicin total alkali solution of 40mg / mL, it is pumped into separation system with 0.02mL / min flow rate from the sample liquid inlet between II district and III district, And the methanol solution flows into the I zone together with the effluent from the IV zone from the eluent inlet between the I zone and the IV zone at a flow rate of 0.19mL / min. The flow rates in areas I to IV were set at 0.9, 0.73, 0.75, and 0.72 mL / min, respectively. Switching time is set to 10min.

[0055] The extract and raffinate were detected by high performance liquid chromatography, and the results showed that the strongly adsorbed components and weakly adsorbed components had been completely separated.

Embodiment 3

[0056] Embodiment 3 improved simulated moving bed separation

[0057] Use methanol / water (volume ratio is 65 / 35) solution to prepare capsaicin compound with a concentration of 40mg / mL, and pump it into the separation system with a flow rate of 1.4mL / min from the inlet of the sample solution between the II area and the III area , and pump pure methanol into the separation system at a flow rate of 0.8 mL / min from the eluent inlet between Zone I and Zone IV. In each switching cycle, when the volume of the effluent from zone IV is less than 1 times the column volume, the effluent from zone IV is mixed with pure methanol and flows into zone I; The methanol / water (volume ratio 65 / 35) solution is pumped into Zone II together. The flow rates in areas I to IV were set at 0.9, 4.5, 5.9, and 3.9 mL / min, respectively. Switching time is set to 10min.

[0058] The extract and raffinate were detected by high performance liquid chromatography, and the results showed that the strongly adsor...

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Abstract

The present invention relates to an improved analog moving bed separation technology, and adopts a chromatographic column as an operation unit, and comprises a first section, a second section, a third section and a fourth section; each chromatographic column can move at a distance the same with the length of a column along the reversing direction of the flow phase in a given period of time so as to perform the interval switching; before the switching, the liquid that flows from the fourth section directly flows into the second section in cycling way; after the switching, after the flow phase of the liquid flows out from the fourth section is formed, the liquid directly flows into a new second section again in cycling way; moreover, the regeneration of the fixed phase of the first section is completed by assembling different solution with the flowing phases from the second section to the fourth section, and the flew liquid is not cycled to flow into the second section, but is completely collected as an extraction solution. The scientific principle for the separation technology of the present invention is the same with the separation principle of the conventional moving bed separation technology, but the separation technology of the present invention can simultaneously resolving the contradiction that the inlet liquid flow rate is large but the washing liquid consumption volume is less, and can obtain large inlet liquid flow rate while reducing the washing liquid consumption volume.

Description

technical field [0001] The invention relates to an improved simulated moving bed separation method. Background technique [0002] In recent years, separation science is facing new challenges: the objects to be separated are becoming more and more complex, and the separation difficulty is becoming more and more difficult. At the same time, the requirements for product purity are getting higher and higher. Batch preparative chromatography, as a high-efficiency separation method, can meet these requirements to a certain extent. However, its industrial application is seriously hindered due to its inherent shortcomings such as large amount of stationary phase and mobile phase, low utilization rate of stationary phase, high dilution of separated products, and high separation cost. The simulated moving bed chromatography (Simulated Moving Bed, SMB), which was born in the 1960s, has been paid more and more attention because it overcomes the shortcomings of batch preparative chromat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/08B01D15/02
Inventor 危凤赵迎宪沈波
Owner NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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