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Composition containing extracts of Butyrospermum parkii and the use as medicament or dietary supplement

An avocado tree and extract technology, which is applied in the directions of medical preparations, drug combinations, food preparations containing active ingredients, etc., can solve the problem of not specifying the chemical composition of flowers in detail.

Inactive Publication Date: 2009-01-21
BSP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent does not detail the chemical composition of the flower, but as far as the inventors are aware, the flower does not contain any substantial amount of avocado-triterpenes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] Research overview

[0127] The possible anti-inflammatory activity of the avocado tree concentrate BPC according to the present invention was evaluated using the BALB / c mouse arthritis model induced by collagen monoclonal antibody (mAb) and lipopolysaccharide. The test substance was orally administered once a day for 3 consecutive days. Significant reductions in hindpaw edema were observed at 50 mg / kg x 3 on days 7, 10, 14 and 17 relative to vehicle-treated controls (57%, 58%, 67% and 78% ). Cyclophosphamide tested in parallel at 10 mg / kg x 3 doses observed 79%, 91% and 90% reductions in hindpaw edema at days 10, 14 and 17 relative to vehicle-treated controls.

[0128] test substance

[0129] The compositions of the present invention are prepared by fractionating shea butter and subsequently diluting the resulting shea concentrate in corn oil. The avocado tree concentrate used (hereinafter referred to as BPC) contained 26% of avocado-triterpene constituents (main...

Embodiment 2

[0154] background

[0155] Four topical pharmaceutical compositions of the present invention containing 5-20% avocado-triterpenes were compared with a conventional cosmetic cream containing shea butter equivalent to 1% avocado-triterpenes.

[0156] The purpose of this study was to compare the pharmacological effects of the composition of the invention with that of known compositions containing shea butter using the established phorbol ester-induced inflammation model in mice for testing topical anti-inflammatory activity.

[0157] method

[0158] Prepare four kinds of compositions of the present invention, a control composition containing shea butter and a negative control composition on the basis of the following cream bases:

[0159] Hydrogenated Rapeseed Oil, Cremeol PS-6, Aarhus Olie, Denmark 10.0%

[0160] Sodium stearoyl lactylate, Danisco Ingredients, Denmark 5.0%

[0161] Sorbitan monostearate, Danisco Ingredients, Denmark 3.0%

[0162] Glyceryl Monostearate, D...

Embodiment 3

[0176] background

[0177] The established phorbol ester-induced mouse inflammation model for testing topical anti-inflammatory activity was used to compare the effects of two topical pharmaceutical compositions of the present invention, one containing 20% ​​avocado-triterpene and the other containing 20% avocado-triterpenes and 0.1% calendula extract.

[0178] method

[0179] Prepare two kinds of compositions of the present invention and negative control composition on the basis of following cream base:

[0180] Hydrogenated Rapeseed Oil, Cremeol PS-6, Aarhus Olie, Denmark 10.0%

[0181] Sodium stearoyl lactylate, Danisco Ingredients, Denmark 5.0%

[0182] Sorbitan monostearate, Danisco Ingredients, Denmark 3.0%

[0183] Glyceryl Monostearate, Danisco Ingredients, Denmark 2.0%

[0184] Methylparaben, Unichem, Denmark 0.3%

[0185] Purified water add to 100%

[0186] The negative control composition was prepared without adding any other additives. Two pharmaceutica...

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PUM

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Abstract

The present invention relates to a composition comprising an extract or a concentrate of Butyrospermum parkii as a dietary supplement or a pharmaceutical composition and to the use of such compositions for the preparation of a medicament or a dietary supplement for the suppression of hypersensitivity and / or inflammatory reaction. The composition may optionally be formulated with a pharmaceutically acceptable carrier for systemic or topical administration. More specifically, the invention relates to a dietary supplement or a pharmaceutical composition comprising an extract or a concentrate of Butyrospermum parkii, wherein said extract or concentrate contains Butyrospermum-triterpenes and optionally the sterols stigmasterol, avanasterol, 24-methyl-cholest-7-enol, karitesterol A, karitesterol B and alpha-spinasterol.

Description

[0001] The application date is July 10, 2000, the application number is 00811168.5 (PCT / DK00 / 00383), and the title of the invention is "composition containing shea butter tree extract and its use as medicine or food supplement". A divisional application of a patent application. technical field [0002] The present invention relates to a food supplement or a pharmaceutical composition for systemic or topical administration comprising a shea tree extract or concentrate optionally formulated with a pharmaceutically acceptable carrier for systemic or topical administration. More specifically, the present invention relates to food supplements or pharmaceutical compositions comprising a shea tree extract or concentrate containing the triterpene alcohols butyryl cetyl alcohol, lupeol, parkeol, Germania alcohol, Mardienol, 24-methylene- Amarenol, α-lipidol and β-lipidol and optionally contain the sterols stigmasterol, avanasterol, 24-methyl-cholest-7-enol, karitesterol A ), canda...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K36/28A61K9/48A23L1/29A23L1/30A61P17/00A61P17/06A61P19/02A61P29/00A61P37/00A61P19/08A61P1/00A23L33/105
Inventor M·S·温德纳
Owner BSP PHARMA
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