Brushite water-hardening gelling material stabilized by magnesium salt

A cementitious material, calcium phosphate rock technology, applied in applications, dental preparations, dental prostheses, etc., can solve problems such as mechanical instability and inflammatory reactions

Inactive Publication Date: 2013-10-16
H C 罗伯特·马泰斯·斯蒂夫腾 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such gelling materials have a too fast resorption rate in the body, leading to mechanical instability and inflammatory responses

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Prepare samples with various gel material compositions. The composition of the gelling material is: 1.33g β-TCP (volume average particle size: 1.1 microns), 0.67g MCPM, 25mg Na 2 H 2 P 2 O 7 , 1g TCP particles (400-500 microns in diameter) and (x)mg Na 2 SO 4 Or MgSO 4 . The mixed liquid is 1g hyaluronic acid water Solution (viscosity: 200mPa·s). Perform three repetitions. The sample preparation is as follows: (i) mix the powder and the solution for 30 seconds, (ii) put the slurry into the end of the gelling material syringe, (iii) measure the curing time, (iv) discharge the sample from the syringe, (v) deionize in 2 mL Aging in water for 24 hours, (vi) drying. In order to measure the pH value, samples of each composition were put into 10 mL of deionized water, and the pH value was measured at regular time intervals. The Brazilian tensile test was used to determine the tensile strength of the sample. The crystal composition of the sample is determined by X-ray diffr...

Embodiment 2

[0043] Design based on experimental factors 2 3 The gelling material samples were prepared in 4 repetitions. These factors are: (A) Sulfate source (Na 2 SO 4 Or MgSO 4 ); (B) the amount of sulfate (20 or 50mg) and (C) Ca 2 P 2 O 7 Quantity (0 / 150mg). The composition of the gelling material: 1.33g β-TCP (volume average particle size: 1.1 microns), 0.67g MCPM, 25mg Na 2 H 2 P 2 O 7 , 1g TCP particles (400-500 microns in diameter) and 20 or 50mg Na 2 SO 4 Or MgSO 4 , And 0 or 150mg Ca 2 P 2 O 7 . The mixed liquid is 1 g of a hyaluronic acid aqueous solution (viscosity: 200 mPa·s). These samples were prepared and analyzed as disclosed in Example 1. The results show that the use of magnesium sulfate to replace sodium sulfate significantly increases the curing time of the cementitious material, and Ca is added to the cementitious slurry 2 P 2 O 7 At this time, the curing time of the cementitious material is significantly reduced. The latter effect is due to an increase in the powde...

Embodiment 3

[0045] The cementitious material sample was prepared by mixing the cementitious material powder and the mixed liquid with a spatula for 60 seconds. Thereafter, the slurry was poured into the syringe and the slurry was injected with the syringe into the cylindrical defect (diameter 8 mm) made in the proximal body or distal leg section / humerus of the sheep. According to the design of experimental factors, 8 kinds of compositions were tested on sheep: (A) Sulfate source (Na 2 SO 4 Or MgSO 4 ); (B)MgHPO 4 ·3H 2 O(0 / 150mg) and (C)Ca 2 P 2 O 7 Quantity (0 / 150mg). The composition of the gelling material is: 5.33g β-TCP (volume average particle size: 1.1 microns), 2.66g MCPM, 100mg Na 2 H 2 P 2 O 7 , 4g TCP particles (400-500 microns in diameter) and 100mg Na 2 SO 4 Or MgSO 4 , And 0 or 600mgMgHPO 4 ·3H 2 O and 0 or 600mg Ca 2 P 2 O 7 . The mixed liquid was 4 mL of a hyaluronic acid aqueous solution (viscosity: 200 mPa·s). Operate on two sheep. The first sheep was slaughtered after t...

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Abstract

A brushite cement for surgical purposes includes a first component including a basic calcium phosphate, a second component including an acidic phosphate, a third component including water, and a fourth component including a source of magnesium used to stabilize an end-product of the setting reaction between the components. The solubility of the source of magnesium is smaller than 100 g / L. The components are chosen in such an amount that (i) the pH of the cement past during setting is lower than 6.0; and (ii) the end-product of the setting reaction comprises dicalcium phosphate dihydrate.

Description

[0001] This application is a Chinese invention patent whose application number is 99817016.X (PCT / CH99 / 00595), the application date is December 9, 1999, and the invention title is "magnesium salt stabilized brushite hydraulic cementitious material" Divisional application of the application. Technical field [0002] The present invention relates to a gelling material for surgical use, and relates to a method for stabilizing brushite, which is used as a temporary bone substitute material and is obtained by the method for producing a temporary bone substitute material of the present invention Temporary bone replacement materials. Background technique [0003] Some calcium phosphate-based hydraulic gelling materials used in surgery are known in the art; they consist of two components (powder / liquid) mixed by internal operations and applied to a suitable paste-like consistency. On the location, it is prepared by curing in situ at that location. The disadvantages of the prior art hydr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/00A61K6/06A61L24/00A61L24/02C04B12/02C04B22/06C04B22/10C04B22/14C04B22/16C04B24/04C04B24/06C04B24/08C04B24/14C04B24/38
CPCC04B28/34A61L27/12A61L24/02C04B2111/00836A61L2430/02C04B14/304C04B22/16C04B2103/0072
Inventor M·博纳S·马特
Owner H C 罗伯特·马泰斯·斯蒂夫腾
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