Medical magnesium alloy/calcium orthophosphate composite material

A composite material and magnesium alloy technology, applied in the field of absorbable medical magnesium alloy/calcium phosphate composite material, can solve the problems of limiting the application of magnesium alloy, inferior to the mechanical properties of bone tissue, generating hydrogen, etc., to reduce the corrosion degradation rate and improve the bone Effects of histocompatibility and osteoinduction

Inactive Publication Date: 2009-01-21
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although clinical applications have proved that magnesium alloys have very good biocompatibility, because magnesium and magnesium alloys corrode and degrade too quickly in the human body, hydrogen gas will be generated, which limits the application of magnesium alloys as implant materials.
Although high-purity magnesium (such as 99.99% high-purity magnesium) has very good NaCl corrosion resistance, its mechanical properties are low and are not as good as those of bone tissue
Although magnesium alloys can achieve high strength, corrosion degradation is fast

Method used

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  • Medical magnesium alloy/calcium orthophosphate composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 40-100 μm high-purity magnesium powder and less than 10 μm calcium phosphate powder (50% hydroxyapatite + 50% β-calcium phosphate, weight ratio) are respectively 10%, 20% and 30% by weight of calcium phosphate powder The ratio is mixed by wet ball milling for 24 hours, and cold pressed to shape. Then in vacuum (vacuum degree is 1×10 -4 Pa) Sintering for 2 hours to form a sintered compact. Finally, it is extruded into rods under certain conditions.

Embodiment 2

[0034] Firstly, Mg-1.0Zn-0.8Mn (weight percent) is smelted on a resistance furnace. The alloy is prepared by using 99.99% pure magnesium and 99.99% pure zinc, and manganese (Mn) in the alloy is added in the form of chemically pure MnCl. Melting is carried out at a volume ratio of 99 to 99.5% CO 2 and 0.5~1%SF 6 (Sulfur hexafluoride) protective atmosphere, the melting temperature is controlled at 700-800 °C. Then add 5-15 μm hydroxyapatite powder according to the weight percentage of 10% and 15% respectively, and adopt the method of mechanical stirring to uniformly mix it with the magnesium alloy liquid. The alloy is then cast into a metal mold and then extruded into a rod-shaped material under certain conditions.

Embodiment 3

[0036] Firstly, Mg-2.0Zn-2.0Ca (weight percent) is smelted on a resistance furnace. The alloy is fused with 99.99% pure magnesium, 99.99% pure zinc and metallic calcium. Melting is carried out at a volume ratio of 99 to 99.5% CO 2 and 0.5~1%SF 6 (Sulfur hexafluoride) protective atmosphere, the melting temperature is controlled at 700-800 °C. Then add 5-20 μm Mg-substituted hydroxyapatite powder (Mg-substituted hydroxyapatite, containing 1.2% Mg, by weight) according to 5% and 15% by weight respectively, and uniformly mix it with the magnesium alloy liquid by means of mechanical stirring. The alloy is then cast into a metal mold and then extruded into a rod-shaped material under certain conditions.

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Abstract

The invention relates to a magnesium alloy or calcium phosphate composite material that can be applied to medical implanted material and is especially suitable for absorbable bone implant material for the human body. The material contains (weight percentage) 1 to 30 percent of calcium phosphate. The calcium phosphate can be one or more of the following substances: calcium phosphate (CaO.P2O5), beta calcium phosphate (3CaO.P2O5), hydroxyapatite (Ca10(PO4)6(OH)2), magnesium hydroxyapatite and silicon hydroxyapatite. The magnesium alloy can be any of high purity magnesium, Mg-Mn, Mg-Zn, Mg-Ca, Mg-Zn-Ca, Mg-Zn-Y, Mg-Zn-Mn and Mg-Zn-Zr alloys. The magnesium alloy base composite material in the invention can adjust the content of the hydroxyapatite to change the strength of the composite material effectively, simultaneously reduce the corrosion and degradation rate of the magnesium alloy and enhance the surface biocompatibility and biological inducibility of the magnesium alloy base composite material.

Description

technical field [0001] The invention relates to a magnesium alloy / calcium phosphate composite material, in particular to an absorbable medical magnesium alloy / calcium phosphate composite material suitable for use in a human body environment. Background technique [0002] In medical bone repair and bone implant materials, stainless steel, titanium and titanium alloys have become widely used materials due to their excellent mechanical properties, biocompatibility and corrosion resistance. However, the mechanical properties of stainless steel and titanium alloys do not match those of bone tissue, especially the modulus of elasticity, so the implant bears almost all the load. This creates "stress shielding" during use, causing atrophy or loosening of the bone tissue surrounding the implant. At the same time, stainless steel and titanium alloy bone nails, bone plates and other implants require follow-up operations to remove them from the human body after the bone tissue has heal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/12A61L27/04A61L31/02
Inventor 张二林杜辉杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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