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A composition and breast cancer technology, applied in the field of medicine, can solve the problems of severe toxic and side effects, and achieve the effect of reducing drug resistance and dosage
Inactive Publication Date: 2009-02-04
BEIJING SHENOGEN BIOMEDICAL
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[0010] In view of the relatively large toxic and side effects of tamoxifen, our research found that if the dosage of tamoxifen ...
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Embodiment 1
[0024] Tamoxifen was purchased from SIGMA-ALDRICH. IC-162 and IC-163 were purchased from Shanghai Yousi Biotechnology Co., Ltd.
Embodiment 2
[0025] Example 2 In Vitro Biological Testing of Pharmaceutical Compositions
[0026] Test 1:
[0027] The combined action of tamoxifen and IC-162 can induce the death of ER-positive breast cancer cell line MCF7.
[0028] experimental method:
[0029] The MCF7 cell line (purchased from the ATCC cell bank) is a breast cancer cell line that highly expresses ERα66 and ERα36, with DMEM / F12 medium (Ivitrogen) containing 10% estrogen-free fetal bovine serum, at 37 ° C, 5% CO 2 After 2 days of cultivation in the incubator. Press 1×10 4 Inoculated at a density of 60 mm in a petri dish, adding concentrations of 0 μ M, 1 μ M, 2 μ M Tamoxifen (TAM) and different concentrations of IC-162 together or different concentrations of IC-162 alone (dissolved and diluted with DMSO), and cultured for 8 days , Count the number of surviving cells with a hemocytometer. Cells were grouped according to drug type and concentration, and 5 culture dishes were grouped.
[0030] Experimental results...
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Abstract
The invention relates to a medicine combination which is used for curing breast cancer and belongs to the chemical medicine field. The invention develops the medicine composition which contains the active ingredient of nolvadex (I) and IC-162 (II) or IC-163 (III), and uses the synergistic mechanism thereof to provide the medicine composition which has good effect on inhibiting breast cancer tumor and can correspondingly reduce the side effect of the nolvadex (I).
Description
technical field [0001] The invention belongs to the field of medicine and relates to an antineoplastic drug, especially a pharmaceutical composition for treating breast cancer. Background technique [0002] Estrogen is a steroid hormone produced by the endocrine system, which plays an important role in the reproductive system, bone tissue, cardiovascular system, immune system and central nervous system [J Cell Sci, 2003; 116(4): 585-586]. The estrogen signaling system plays an important role in the regulation of cell growth, differentiation and apoptosis. The occurrence and development of estrogen-dependent tumors, such as breast cancer, ovarian cancer and endometrial cancer, are closely related to estrogen [J Steroid Biochem.Mol.Biol., 2002, 81(1): 1-24 , J Mammary Gland Biol. Neoplasia, 1998, 3(1): 49-61, Curr. Drug Targets Immune Endocr. Metabol. Disord; 2001, 1(1): 1-12, Cancer Res., 1998, 58(23) : 5367-5373, J Psychiatry Neurosci, 2002; 27 (1): 1-27], so the research...
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