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Bromhexine hydrochloric acid orally disintegrating tablet production method

An orally disintegrating tablet and production method technology, applied in the field of powder feeder for new tablet presses, can solve the problems of inability to realize industrialized production, poor tablet compressibility, tablet weight difference, etc., and achieve cool and delicate taste, high tablet weight Effect of small variance, high dissolution rate and high dissolution rate

Inactive Publication Date: 2009-02-11
HONGYI SCI & TECH CO LTD NANCHANG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In China, the preparation technology of orally disintegrating tablets started relatively late. At present, most of the orally disintegrating tablets are prepared by direct compression method. The degree of crushing, disintegration, and dissolution are difficult to control, and the compressibility of the tablet is poor, so industrial production cannot be realized

Method used

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  • Bromhexine hydrochloric acid orally disintegrating tablet production method
  • Bromhexine hydrochloric acid orally disintegrating tablet production method
  • Bromhexine hydrochloric acid orally disintegrating tablet production method

Examples

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example 1

[0024]

[0025]

[0026] Bromhexine hydrochloride and mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, croscarmellose sodium, crospovidone, aspartame, micronized silica gel, magnesium stearate After being pulverized separately, mixed and sieved according to the prescription weight ratio, the final mixed fine powder is placed in a powder feeder for a new tablet machine, and compressed into tablets to produce bromhexine hydrochloride orally disintegrating tablets.

example 2

[0028]

[0029] Bromhexine hydrochloride and mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, croscarmellose sodium, crospovidone, aspartame, micronized silica gel, magnesium stearate After being pulverized separately, mixed and sieved according to the prescription weight ratio, the final mixed fine powder is placed in a powder feeder for a new tablet machine, and compressed into tablets to produce bromhexine hydrochloride orally disintegrating tablets.

example 3

[0031]

[0032]

[0033]Bromhexine hydrochloride and lactose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, croscarmellose sodium, crospovidone, aspartame, micronized silica gel, magnesium stearate After pulverization, mix and sieve according to the prescription weight ratio, and put the total mixed fine powder into a powder feeder for a new tablet machine, and compress into tablets to produce bromhexine hydrochloride orally disintegrating tablets.

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Abstract

The invention relates to a medical prescription for producing bromhexine hydrochloride orally disintegrating tablets by using powder direct compression process, a technology and a powder feeder used for a novel tablet machine. Compared with the conventional technique of the powder direct compression process, the orally disintegrating tablets produced by the invention has mouth-feel of cool-refreshing and fine-smooth, smaller tablet weight difference, good content uniformity, fast disintegration and dissolution, high dissolution speed and dissolution rate, strong hardness and good compressibility of the tablets.

Description

technical field [0001] The invention relates to a prescription and a process for producing bromhexine hydrochloride orally disintegrating tablets by a direct powder compression method and a novel powder feeder for a tablet machine. Background technique [0002] Bromhexine hydrochloride and its tablets are recorded in the Chinese Pharmacopoeia. It was the earliest active ingredient of the Indian folk expectorant and cough medicine Duckbill. It was first synthesized by Keck in 1963, developed by Boehringer Inger, and listed in 1965. Applied in Germany, Italy, UK, France and other countries. my country produced it in 1973. [0003] Bromhexine hydrochloride is a derivative of Vasicine, which has a strong mucolytic effect. It mainly acts on the mucus-producing cells of the trachea and bronchial mucosa, inhibits the synthesis of acidic mucopolysaccharide proteins in sputum, and can break the mucin fibers in sputum, thus restoring the rheological properties of trachea and bronchi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/136A61P9/10A61J3/10
Inventor 刘智钱进穆正义陶琳廖新华刘春阳熊水根陈晓华周治洋段建华颜锋刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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