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Medicine combination for treating diabetic peripheral neuropathy and preparation method thereof

A technology for peripheral neuropathy and composition, applied in the direction of drug combination, nervous system disease, pharmaceutical formulation, etc.

Active Publication Date: 2012-11-14
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation methods of the above applications (patents) mostly adopt conventional water extraction, or directly pulverize and prepare. Most of the prescriptions are based on promoting blood circulation and removing blood stasis. The disadvantages are that the process is rough and the effective parts are not clear. The efficacy and quality of the drug cannot be guaranteed

Method used

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  • Medicine combination for treating diabetic peripheral neuropathy and preparation method thereof
  • Medicine combination for treating diabetic peripheral neuropathy and preparation method thereof
  • Medicine combination for treating diabetic peripheral neuropathy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] The raw materials were weighed according to the following proportions: 9 parts of astragalus, 6 parts of Ligustrum lucidum, 6 parts of cassia twig, 6 parts of red peony root, 6 parts of scutellaria baicalensis, 6 parts of berberine, and 2 parts of leech.

[0069] Preparation:

[0070] (1) Measure astragalus, red peony root, scutellaria baicalensis, and cassia twig according to the formula, add 5-10 times the amount of 60-80% ethanol to reflux and extract twice, each time for 1-2 hours, filter, combine the second extracts, and decompress Recover ethanol, concentrate, be extract 1, set aside;

[0071] (2) Take Ligustrum lucidum and Coptis chinensis according to the formula, add 8 to 12 times the amount and decoct twice, each time for 1 to 2 hours, filter, combine the secondary extracts, concentrate to 50°C and measure the relative density to 1.15 to 1.20, add ethanol until the alcohol content reaches 65%, let it stand overnight, filter the supernatant, recover the ethan...

Embodiment 2

[0075] The raw materials were weighed according to the following proportions: 48 parts of astragalus, 24 parts of Ligustrum lucidum, 24 parts of cassia twig, 24 parts of red peony, 24 parts of skullcap, 24 parts of coptis, and 18 parts of leech.

[0076] Preparation:

[0077] (1) Measure astragalus, red peony root, scutellaria baicalensis, and cassia twig according to the formula, add 5-10 times the amount of 60-80% ethanol to reflux and extract twice, each time for 1-2 hours, filter, combine the second extracts, and decompress Recover ethanol, concentrate, be extract 1, set aside;

[0078] (2) Take Ligustrum lucidum and Coptis chinensis according to the formula, add 8 to 12 times the amount and decoct twice, each time for 1 to 2 hours, filter, combine the secondary extracts, concentrate to 50°C and measure the relative density to 1.15 to 1.20, add ethanol until the alcohol content reaches 65%, let it stand overnight, filter the supernatant, recover the ethanol under reduced...

Embodiment 3

[0082] The raw materials were weighed according to the following proportions: 30 parts of astragalus, 15 parts of Ligustrum lucidum, 10 parts of cassia twig, 10 parts of red peony, 10 parts of skullcap, 10 parts of berberine, and 6 parts of leech.

[0083] Preparation:

[0084] (1) Measure astragalus, red peony root, scutellaria baicalensis, and cassia twig according to the formula, add 5-10 times the amount of 60-80% ethanol to reflux and extract twice, each time for 1-2 hours, filter, combine the second extracts, and decompress Recover ethanol, concentrate, be extract 1, set aside;

[0085] (2) Take Ligustrum lucidum and Coptis chinensis according to the formula, add 8 to 12 times the amount and decoct twice, each time for 1 to 2 hours, filter, combine the secondary extracts, concentrate to 50°C and measure the relative density to 1.15 to 1.20, add ethanol until the alcohol content reaches 65%, let it stand overnight, filter the supernatant, recover the ethanol under reduc...

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Abstract

The invention relates to a pharmaceutical composition for curing peripheral neuropathy of diabetes and a preparation method thereof. The composition of the invention mainly consists of Astragalus root, glossy privet fruit, cassia twig, radix paeoniae rubra, radix scutellariae, coptis root and leeches, is a medicine manufactured with a carrier or an exipient acceptable in pharmacy and in types of capsule, granule, tablet, soft capsule, guttate pill and the like. The composition of the invention has effects in supplementing qi, nourishing yin, detoxificating, dissolving the stagnant and activating channels, and is applicable to patients suffering from peripheral neuropathy of diabetes. The clinical research shows that the composition of the invention can obviously improve such symptoms of the patients suffering from peripheral neuropathy of diabetes as numbness of the limbs, sore limbs, warmlessness of acral, abnormal sensation, exhaustion and the like, as well as imposing an obvious improvement on nerve conducting speed and ending microcirculation. With the adoption of the composition of the invention, the sorbitol content in red blood cell decreases obviously, without any obvious untoward reaction.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition for treating diabetic peripheral neuropathy and a preparation method thereof. 2. Background technology [0002] Diabetic peripheral neuropathy (DPN) is one of the common complications of diabetes, and the clinical incidence rate is relatively high. According to the research on the prevalence of neuropathy in diabetic (DM) population in Rochester, Minnesota, USA, 60% to 80% of diabetic patients have There is one or more forms of neuropathy, which can involve any peripheral nerve and seriously endanger the patient's physical health. Although it is not the main cause of death in DM patients, it is indeed the main factor of disability in DM patients, and it is one of the main causes of chronic refractory ulcers of lower limbs and feet, dry gangrene, wet gangrene and amputation (toes) in diabetic patients. . At present, 50% to 75% of amputations caused by non-traumatic reasons are caused by diabetic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P3/10A61P25/02A61K35/62
Inventor 刘铜华
Owner BEIJING UNIV OF CHINESE MEDICINE