Protein-polymer conjugates
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- PHARMAESSENTIA CORP
- Publication Date
- 2013-11-20
Smart Images
Figure 1 
Figure 2 
Figure 3
Abstract
Description
technical field
[0001] The present invention relates to protein-polymer conjugates, and more particularly to conjugates comprising one or more polymer moieties, protein moieties and linkers. The invention also relates to methods for the preparation of said protein-polymer conjugates and their use in the treatment of hepatitis B virus infection or hepatitis C virus infection. Background technique
[0002] Advances in cell biology and recombinant protein technology have led to the development of protein therapeutics.
[0003] However, there are still major obstacles. Most proteins are susceptible to proteolytic degradation and thus have a short half-life in the circulation. Other disadvantages include low water solubility and induction of neutralizing antibodies.
[0004] The attachment of polymers such as polyethylene glycol (PEG) to proteins hinders the access of proteolytic enzymes to the protein backbone, resulting in increased protein stability. Additionally, it incre...