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Vaccine sustained-release agent for birds as well as preparation and inoculation method thereof

A slow-release agent and vaccine technology, which is applied in the field of poultry vaccine slow-release agents, can solve the problems of prevention effect, difficulty in absorption, and impact on egg production, etc., and achieve the goal of ensuring normal growth and development, wide range of performance changes, and prolonging the action time Effect

Active Publication Date: 2009-03-04
SHANXI HAISEN BIOLOGIC PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that this stress response will affect the growth and egg production rate of chickens to a certain extent, especially the injection and vaccination during egg production will directly affect the normal production of chickens and cause the egg production rate to drop by 2 to 5%.
For example, the Newcastle disease oil vaccine for chickens and chicken egg production drop syndrome oil vaccine have a large injection volume per chicken, slow absorption, and affect egg production.
[0005] Secondly, since the adjuvant white oil accounts for a large proportion in the preparation of oil seedlings, the vaccination volume of the vaccine increases. Generally, it takes one to two weeks for the vaccine to cause the chicken to be stimulated by the antigen to produce antibodies, and the antibody level after vaccination will also change accordingly. With the prolongation of inoculation time, it will gradually decrease, which will affect the preventive effect to a certain extent.
[0006] Third, there are many oil adjuvants in the current injection vaccines, which are not only difficult to absorb, but also have certain toxic and side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 80g of freeze-dried chicken Newcastle disease inactivated oil seedlings, 8g of controlled-release agent, and 12g of propolis. After passing the sterility test, immunization period test and safety test, store it in an environment of 2-8°C for later use.

[0025] When in use, use an inoculation needle to pierce the neck skin of the chicken, and insert the tablet to complete the Newcastle disease inoculation.

Embodiment 2

[0027] Take 40g of freeze-dried Newcastle disease inactivated oil seedlings and 44g of freeze-dried chicken egg production drop syndrome inactivated oil seedlings, 6g of controlled-release agent and 10g of propolis, mix them evenly, and press them under aseptic conditions to form slow-release vaccines with a diameter of 2.5 mm The tablets are divided into sterilized 50mL bottles and stored in an environment of 2-8°C for later use after passing the sterility test, immunity period test and safety test.

[0028] When the laying hen reaches 100 days of age, use an inoculation needle to pierce the neck skin of the chicken, insert the above-mentioned vaccine slow-release tablet, and complete the inoculation of the dual vaccine against Newcastle disease and egg production drop syndrome.

Embodiment 3

[0030] Take freeze-dried chicken Newcastle disease inactivated oil seedling 24g, freeze-dried avian influenza inactivated oil seedling 20g, freeze-dried infectious bronchitis inactivated oil seedling 20g, freeze-dried chicken egg production drop syndrome inactivated oil seedling 24g, and controlled release agent Mix 5g of propolis and 7g of propolis evenly, press under aseptic conditions into vaccine slow-release tablets with a diameter of 2.8 mm, pack them in sterilized 50mL bottles, pass the sterility test, immunity period test and safety test, and store in Store at 2-8°C for later use.

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Abstract

A poultry vaccine sustained-release preparation in form of a sustained-release tablet is prepared by mixing lyophilized poultry vaccine inactivated antigen, a release controlling agent and propolis, and tabletting under aseptic conditions. The inoculation method of the sustained-release tablet is to implant the table subcutaneously at the neck of poultry by use of a special implanter. The inoculation of the vaccine sustained-release preparation avoids stress reaction of poultry, prolongs the action time of the poultry vaccine, reduces the use amount of an oil adjuvant in the vaccine, keeps high level of the antibody for a long time, and protects the normal growth development and egg laying of poultry from interference. The poultry vaccine sustained-release preparation is mainly used for single or multiple vaccination prevention of chicken diseases, and is also suitable for vaccination of other poultry. The poultry vaccine sustained-release preparation has the simple inoculation method, thereby facilitating popularization and application.

Description

technical field [0001] The invention relates to an animal vaccine, in particular to a poultry vaccine sustained release agent. The invention also relates to the preparation and inoculation method of the slow-release vaccine for poultry. Background technique [0002] The aquaculture industry in my country has developed rapidly and has a large scale, among which the annual stock of laying hens alone is as high as more than 1.5 billion. Chickens will be threatened by many diseases during their growth and development, especially Newcastle disease, fowl pox, infectious bronchitis and egg production drop syndrome, etc., which are viral and recurrent infectious diseases of chickens, and are widely spread in the world, especially in Asia. Widely prevalent in the region. These diseases spread quickly and have high mortality rates, which are extremely harmful to the chicken industry. For chicken farmers, the prevention and treatment of chicken diseases is the key to the success of ...

Claims

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Application Information

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IPC IPC(8): A61K39/00A61K39/12A61K39/295A61K9/22A61K47/34A61P31/04A61P31/00A61P31/12
Inventor 乔云龙孙建刚
Owner SHANXI HAISEN BIOLOGIC PRODS