Preparation method of arginine aspirin and powder and injection preparation thereof

A technology of arginine aspirin and aspirin, which is applied in the field of medicine, can solve problems such as long time, high cost, and low efficiency, and achieve the effect of saving time and improving efficiency

Inactive Publication Date: 2009-03-11
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the shortcomings of long time, high cost and low efficiency in the preparation method of arginine aspirin i

Method used

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  • Preparation method of arginine aspirin and powder and injection preparation thereof
  • Preparation method of arginine aspirin and powder and injection preparation thereof
  • Preparation method of arginine aspirin and powder and injection preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 arginine aspirin

[0022] (1) Dissolve 209.1g of arginine in water for injection, add 180.2g of aspirin, stir evenly, raise the temperature to 80°C, keep stirring for 4h, make it fully react, and obtain a clear solution; filter, add an appropriate amount of chloroform, and stir for 40min , stored at a low temperature of 2-8°C for 10 hours, precipitated out, filtered, washed with an appropriate amount of ethanol, and vacuum-dried at 50°C for 6 hours to obtain 303.3 g of arginine aspirin crude product;

[0023] (2) Put 303.3g of arginine aspirin crude product and 2420ml of 80% ethanol solution into the reaction flask, heat to 70°C, stir to make all the solids dissolve, add 2.72g of gac (equivalent to adding 0.1g gac to 1ml solution), stir for 30min, Filtrate, add an appropriate amount of absolute ethanol to the filtrate, place it at 2-8°C for low-temperature crystallization, filter, wash the filter cake with ethanol, and dry it in vacuum at...

Embodiment 2

[0024] The preparation of embodiment 2 arginine aspirin

[0025] (1) Dissolve 418.3g of arginine in water for injection, add 360.5g of aspirin, stir evenly, raise the temperature to 60°C, keep stirring for 2h, make it fully react, and obtain a clear solution; filter, add an appropriate amount of chloroform, and stir for 20min , stored at 2-8°C for 20 hours at a low temperature, precipitated, filtered, washed with an appropriate amount of ethanol, and vacuum-dried at 70°C for 4 hours to obtain 597.2 g of arginine aspirin crude product;

[0026] (2) Put 597.2g of arginine aspirin crude product and 4800ml of 80% ethanol solution into the reaction flask, heat to 60°C, stir to make all the solids dissolve, add 24.33g of activated carbon (equivalent to 1ml solution plus 0.5g of activated carbon), stir for 10min, Filtrate, add an appropriate amount of absolute ethanol to the filtrate, place it at 2-8°C for low-temperature crystallization, filter, wash the filter cake with ethanol, an...

Embodiment 3

[0028] The refined product of aspirin arginine prepared in Example 1 was subpackaged under 100-grade clean conditions in a sterile room, and each bottle contained 0.5 g of aspirin arginine to obtain aspirin arginine powder for injection.

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PUM

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Abstract

The invention discloses an aspirin arginine and a preparation method of powder for injection thereof, the preparation method is characterized in that: arginine is dissolved in water, aspirin is further added, the arginine fully reacts with the aspirin in the water by stirring at the reaction temperature of 60-80 DEG C, chloroform is added after the reaction, the low temperature preservation, the precipitation and the filtration are carried out, sediment is washed and vacuum dried, an aspirin arginine crude product is obtained, and then the aseptic packaging or the freeze-drying after the redissolution is carried out to obtain the aspirin arginine powder for injection. The method has short reaction time and high production efficiency, and the obtained aspirin arginine powder for injection has stable product quality.

Description

technical field [0001] The invention relates to a preparation method of arginine aspirin, in particular to a preparation method of arginine aspirin powder for injection, which belongs to the technical field of medicine. Background technique [0002] Since Aspirin was developed by Bayer Company of Germany in 1897, it has been used for a hundred years. It is the most common non-steroidal antipyretic, analgesic and anti-inflammatory drug in clinical practice. Aspirin drugs have been widely used in the world due to their wide range of applications, especially the prevention and treatment of some diseases that seriously endanger human health such as cardiovascular diseases, and they are cheap and easy to use. and research. [0003] Aspirin, as an antipyretic and analgesic, is widely produced and used in my country. The biggest disadvantage is that it has a strong stimulating effect on the gastric mucosa after oral administration. Aspirin can cause side effects such as stomach d...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61K31/198A61P29/00
Inventor 王明
Owner HAINAN LINGKANG PHARMA CO LTD
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