Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Propellane compounds, preparation method and application thereof

A compound, propane technology, applied in the field of propane compounds, can solve the problems of low addiction and limited application, etc.

Inactive Publication Date: 2009-04-08
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
View PDF1 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the tolerance and dependent side effects of this type of drug, its application is greatly limited.
κ-opioid receptor agonists also have powerful analgesic effects, but are low in addiction. Therefore, research and development of new opioid analgesics with low addiction is of great clinical significance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Propellane compounds, preparation method and application thereof
  • Propellane compounds, preparation method and application thereof
  • Propellane compounds, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0045] 1 HNMR was measured with a Varian Mercury AMX300 instrument; MS was measured with a VGZAB-HS or VG-700 instrument, and all were EI sources (70ev) unless otherwise specified; all solvents used were re-distilled or anhydrous before use; all All the reactions were carried out under the protection of argon, and the progress of the reaction was tracked by TLC. Post-treatments were washed with saturated brine and dried over anhydrous sodium sulfate; unless otherwise specified, silica gel (200-300 mesh) column chromatography was used for product purification; silica gel and silica gel plates used included 200-300 mesh silica gel and GF254 silica gel plate. Both are products of Qingdao Ocean Chemical Factory or Yantai Yuanbo Silicone Co., Ltd.

[0046] 1. Preparation of Compound 2 (X=OMe, R'=Me)

[0047] Compound 3 (X=OMe, R'=Me) (5.67g, 18.0mmol) was dissolved in 100mL of mixed acid of acetic acid and concentrated hydrochloric acid, refluxed at 120°C, and zinc powder (17.7g...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses propellane compounds, a preparation method and application thereof, in particular aromatic or fat thick heterocyclic propellane compounds, a preparation method thereof and applications for treating drug abuse as an opioid receptor excitant or an antagonist and for using as a novel analgesic agent and so on. The structures of the compounds are shown in a general formula (I).

Description

technical field [0001] The present invention relates to a class of propeller alkanes and its preparation method, as opioid receptor agonist or antagonist, to treat drug abuse and brain dysfunction related to drug abuse, and as a new type of analgesic. Background technique [0002] Drug abuse is a serious social and economic problem that directly endangers human health and destroys family unity. It is a chronic disease of the brain caused by long-term excessive use of excitatory substances such as cocaine and heroin. It is characterized by a slow course of disease and high relapse, accompanied by obvious psychological, intellectual and behavioral disorders [Crome, HB. Drug Alcohol Depend. 1999, 55: 247-263; NIDA (2000): Epidemiologic Trends in Drug Abuse, NIH Publication No. 00-4739A. National Institute on Drug Abuse, 99]. In recent years, with the development of neurobiology, neuropharmacology, molecular biology, molecular genetics, brain imaging technology, etc., human be...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D471/04C07D221/18A61K31/437A61P25/04A61P25/00
Inventor 张翱谢欣李付营
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com