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Vascular undercoat stent

An inner coating and blood vessel technology, applied in stents, coatings, medical science, etc., to achieve the effect of inhibiting smooth muscle hyperplasia, uniform coating distribution, and no cracking

Inactive Publication Date: 2012-07-04
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in prior art, silk fibroin peptide and chitosan are not used as coating materials for any report on scaffold modification

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0059] Figure 4 It is a schematic diagram of the preparation process of the intravascular coated stent of the present invention. As can be seen:

[0060] The preparation method of endovascular coated stent of the present invention comprises the following steps:

[0061] (1) coating and forming a polymer bottom layer on the surface of the stent body;

[0062] (2) Alternate coating on the surface of the polymer bottom layer to form multiple silk fibroin peptide layers and chitosan layers.

[0063] The coating comprises a polymer bottom layer, a multi-layer silk fibroin peptide layer and a chitosan layer.

[0064] In the above-mentioned preparation method, when the polymer bottom layer is coated on the surface of the stent body, the solution used is an aqueous solution of NaCl containing polyethyleneimine, wherein the concentration of polyethyleneimine is 5-10mg / ml, and the soaking time is 10 -60 minutes.

[0065] In the above-mentioned preparation method, when the silk fi...

Embodiment 1

[0085] Embodiment 1 Hydrophilicity experiment of endovascular coating stent of the present invention

[0086] Experimental instrument: The contact angle of the coating surface was measured by an OCA20 video optical contact angle measuring instrument (manufactured by Dataphysics Instrument Company, Germany). Measurement accuracy: ±0.1°.

[0087] Experimental material: 316L stainless steel was used as the support body, and 12 pieces of coated supports were prepared by using the above-mentioned electrostatic self-assembly method of the present invention. The first layer of coating is composed of polyethyleneimine layer and 1 layer of silk peptide layer; the second layer of coating is polyethyleneimine layer, 1 layer of silk peptide layer and 1 layer of chitosan from inside to outside The third layer of coating is composed of polyethyleneimine layer, (silk fibroin peptide layer + chitosan layer) 1+ silk fibroin peptide layer from inside to outside; the fourth layer of coating is ...

Embodiment 2

[0090] Embodiment 2 Anticoagulant effect experiment of endovascular coating stent of the present invention

[0091] Experimental materials: 6 pieces of 316L stainless steel endovascular coated stents prepared according to the above-mentioned electrostatic self-assembly method of the present invention (1 layer of polyethyleneimine layer, 21 layers of multi-layer silk fibroin peptide layer and chitosan layer) and only the surface Clean 6 pieces of uncoated 316L stainless steel brackets.

[0092] Experimental method: drop 0.1ml of anticoagulated human blood on the surface of the stent, add 0.01ml of CaCl with a micro-sampler 2 Solution (0.2mol / l), gently stir with a micro-syringe needle, and immediately record the time, at 10, 20, 30, 40, 50, 60min, wash with 50ml of distilled water respectively, collect the washing liquid in a beaker, and use 756MC The absorbance OD-time curve was tested at a wavelength of 540nm by an ultraviolet spectrophotometer, and compared with the uncoate...

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Abstract

The invention relates to a medical product for interventional therapy, in particular to a novel intravascular coated stent which comprises a stent body and a coat. The coat comprises a polymer bottom layer formed by coating on the surface of the stent body and multilayer silk peptide layers and chitosan layers which are formed by coating on the surface of the polymer bottom layer, wherein the silk peptide layers and the chitosan layers are arranged alternately. A stent coat is prepared by a method of layer upon layer electrostatic self-assembly, has better compatibility with blood, and can reduce late restenosis rate of stent post-operative heart.

Description

technical field [0001] The invention relates to a medical product for interventional therapy, in particular to a new coated stent in a blood vessel, especially to modify the metal surface by using silk fibroin peptide and chitosan through a layer-by-layer electrostatic self-assembly method to make it compatible with blood It has better compatibility and can reduce the rate of late restenosis of cardiovascular vessels after stenting. Background technique [0002] In 1987, Sigwart et al. used intravascular metal stents for coronary arteries for the first time, and received unexpected results, which provided a good way for the treatment of vascular occlusion diseases. Coronary artery stent is a kind of intravascular stent made of metal stainless steel, which has good plasticity and geometric stability, and can be sent to the lesion site through a catheter in a closed state, and then expanded by balloon expansion. Play a role in supporting blood vessels. Coronary artery stent ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02A61L31/10A61F2/82
Inventor 刘建平蒋容静李晓燕曹梅讯
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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