Preparation method of beche-de-mer capsules
A technology of sea cucumbers and capsules, which is applied in the field of sea cucumber pharmaceutical preparations, and can solve problems that do not mention the degree and effect of sea cucumbers being used
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Embodiment 1
[0017] Embodiment 1: make sea cucumber nanopowder capsule with fresh and alive sea cucumber
[0018] 1. Take 1000 grams of fresh sea cucumber, take out the internal organs, and clean the body wall.
[0019] 2. Mince the washed sea cucumber body wall, put it in an airtight container for high temperature treatment, 100-103°C, 10h.
[0020] 3. After cooling, vacuum freeze-drying, the moisture after drying is less than 3%.
[0021] 4. Use a coarse pulverizer YF300 traditional Chinese medicine pulverizer for 20 minutes of coarse pulverization, and measure the particle size within the range of 10 to 300 mesh.
[0022] 5. Ultrafine pulverization with jet mill QS350, the pulverization fineness is 100-3000 mesh.
[0023] 6. Grinding with a high-energy nano ball mill for 10 hours.
[0024] The particle size distribution of the product is shown in the table below:
[0025] particle size determination
[0026] Particle size (nm) Area ratio of histogram (%nm) Mass fractio...
Embodiment 2
[0029] Embodiment 2: make sea cucumber nanopowder capsule with fresh sea cucumber
[0030] 1. Take 1000 grams of fresh sea cucumber, and clean the internal organs and body wall.
[0031] 2. Mince the washed sea cucumber body wall and viscera, and place it in a closed container for 20 hours at 80-85°C.
[0032] 3. After cooling, vacuum freeze-drying, the moisture after drying is less than 8%.
[0033] 4. Use a coarse pulverizer YF300 traditional Chinese medicine pulverizer for 10 minutes of coarse pulverization, and measure the particle size within the range of 10 to 300 mesh.
[0034] The following steps are the same as in Example 1.
Embodiment 3
[0035] Embodiment 3: make sea cucumber nano-powder capsules with dried sea cucumber
[0036] 1. Take the dried sea cucumber and make it with water in the usual way and clean it.
[0037] 2. Mince the cleaned sea cucumbers, place them in a closed container for high temperature treatment, 110-115°C, 10h.
[0038] 3. After cooling, vacuum freeze-drying, the moisture after drying is less than 5%.
[0039] 4. Use a coarse pulverizer YF300 traditional Chinese medicine pulverizer for 20 minutes of coarse pulverization, and measure the particle size within the range of 10 to 300 mesh.
[0040] 5. Ultrafine pulverization with jet mill QS350, the pulverization fineness is 100-3000 mesh.
[0041] 6. Use a high-energy nano ball mill for crushing, the crushing time is 10 hours, and the particle size is 10-300nm. Pack into capsules with an automatic capsule filling machine, 0.25g per capsule.
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