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Uses of medicament composition in preparing medicament for inhibiting albumin leakage

A technology of composition and albumin, which is applied in the field of medicine, can solve problems such as the improvement effect of cerebral microcirculation disorder, which has not been reported.

Inactive Publication Date: 2009-05-13
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on whether Yangxue Xuenao Granules can improve the cerebral microcirculation disorder caused by ischemia-reperfusion, especially the study on the effect of Yangxue Xuenao Granules on inhibiting albumin leakage and improving microcirculation.

Method used

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  • Uses of medicament composition in preparing medicament for inhibiting albumin leakage
  • Uses of medicament composition in preparing medicament for inhibiting albumin leakage
  • Uses of medicament composition in preparing medicament for inhibiting albumin leakage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment one pharmaceutical composition preparation

[0064] (1) Take 67.5g of Angelica, 67.5g of Chuanxiong, 54g of Radix Paeoniae Alba, 54g of Rehmannia Rehmanniae, 135g of Spatholobus Spatholobus, 135g of Prunella vulgaris, 135g of Cassia Seed, 135g of Mother of Pearl, 67.5g of Rhizoma Rhizoma Rhizoma, 14.5g of Asarum;

[0065] (2) Add water to extract the above medicinal materials 3 times, each time for 1 hour, combine the extracts, concentrate appropriately, add 2 times the amount of ethanol, let stand for 24 hours to precipitate, take the supernatant and concentrate it into an extract, with a relative density of 1.4, The paste yield is 10%. Take clear paste, sucrose and dextrin at a ratio of 1:3:1 to make 125 bags of granules.

Embodiment 2

[0066] Embodiment two pharmaceutical composition formulations

[0067] (1) Take 80g of Angelica, 80g of Chuanxiong, 80g of Paeoniae Alba, 80g of Rehmannia Rehmanniae, 120g of Uncle Teng, 120g of Spatholobus, 120g of Prunella vulgaris, 120g of Cassia Seed, 120g of Mother of Pearl, 70g of Rhizoma Rhizoma Rhizoma, 10g of Asarum;

[0068] (2) Add water to extract the above medicinal materials 3 times, each time for 1 hour, combine the extracts, concentrate appropriately, add 2 times the amount of ethanol, let stand for 24 hours to precipitate, take the supernatant and concentrate into an extract, the relative density is 1.3, The paste yield is 10%. Take clear paste, sucrose and dextrin at a ratio of 1:3:1 to make 200 tablets.

Embodiment 3

[0069] Embodiment three Chinese medicine composition preparation

[0070] (1) Take 40g of Angelica, 40g of Chuanxiong, 20g of Paeoniae Alba, 20g of Rehmannia Rehmanniae, 100g of Uncle Teng, 100g of Caulis Spatholobus, 100g of Prunella vulgaris, 100g of Cassia Seed, 100g of Mother of Pearl, 70g of Rhizoma Rhizoma Rhizoma, 10g of Asarum;

[0071] (2) Add water to extract the above medicinal materials 3 times, each time for 1 hour, combine the extracts, concentrate appropriately, add 2 times the amount of ethanol, let stand for 24 hours to precipitate, take the supernatant and concentrate into an extract, the relative density is 1.3, The paste yield is 10%. Take clear paste, sucrose and dextrin at a ratio of 1:3:1 to make 100 capsules.

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Abstract

The invention relates to the application of a pharmaceutical composition for preparing a medication for preventing albumin from externally leaking, which belongs to the field of medicine. The pharmaceutical composition is proved for the first time that the pharmaceutical composition can prevent the albumin from externally leaking to the blood vessel of the small vein of the cerebral cortex of the gerbil due to the ischemia reperfusion through the dynamic, continuous and visual observation to the albumin marked with FITC in the small vein of the cerebral cortex of the gerbil and externally leaking to the small vein due to the ischemia reperfusion, and the invention is the ideal drug for preventing and curing the microcirculatory disturbance caused by external leakage of the albumin.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Yangxueqingnao Granules in the preparation of drugs for inhibiting albumin leakage. Background technique [0002] The average incidence of cerebrovascular disease in the world is 140-200 / 100,000 population, and the average mortality rate is 100 / 100,000 population, which is a disease with high morbidity and mortality. Improving cerebrovascular injury is of great significance to saving lives and reducing medical costs. Cerebrovascular injury caused by ischemia-reperfusion accounts for about 60% of the causes of cerebrovascular injury. After ischemia-reperfusion, the leukocytes adhered to the vascular endothelium release a large amount of peroxidase and protease, damage the vascular endothelial cells and basement membrane, cause increased vascular permeability and leakage of plasma albumin, resulting in edema of the perivascular tissue. Peroxide stimulation c...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P9/10A61K35/56A61K35/618
Inventor 韩晶岩徐想顺
Owner TIANJIN TASLY PHARMA CO LTD
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